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Paper Information

Journal:   IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)   AUGUST-SEPTEMBER 2016 , Volume 19 , Number 3 ; Page(s) 372 To 384.
 
Paper: 

THE EFFECTS OF TESTOSTERONE INTRAUTERINE DISTURBANCE ON SPERM QUALITY AND TESTIS TISSUE IN MALE RAT'S OFFSPRING AFTER PUBERTY

 
DOI: 

10.18869/acadpub.ismj.19.3.372

 
Author(s):  NOROOZZADEH M., RAMEZANI TEHRANI F.*, ZADEH VAKILI A., PIRYAEI A., GHASEMI A., AZIZI F.
 
* REPRODUCTIVE ENDOCRINOLOGY RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Environmental factors and hormonal disorders during prenatal life can impair the evolution and differentiation of fetus’s reproductive system. The aim of this study was to the examination of sperm quality and testis tissue in adult rats that had exposed to exogenous testosterone during their prenatal life.
Materials & Methods: Pregnant rats divided into two experimental and control groups. In experimental group, pregnant rats daily were subcutaneously injected with 3 mg exogenous testosterone during gestational days 16-19, and controls received solvent. The reproductive system was examined in male offspring of these animals after puberty. Data analysis was performed by using the SPSS software (version 15). Distributions between groups are compared by using the Mann-Whitney test.
Results: In the offspring of experimental group, motility and the number of sperm were significantly decreased (P<0.05). No morphological abnormality was observed in sperm in two groups. The numbers of sertoli cells, ratios of spermatocyte and round spermatid cells were significantly decreased in the offspring of experimental group (P<0.05). No significant difference was observed in seminiferous tubules diameter between the two groups. Serum testosterone levels were significantly decreased in offspring from experimental group (P<0.05).
Conclusion: The present study showed that prenatal exposure to testosterone leads to decrease of sperm quality and changes in testis tissue in male rats, after puberty.

 
Keyword(s): PRENATAL LIFE, TESTOSTERONE, SPERM QUALITY, TESTIS, RAT
 
 
References: 
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Click to Cite.
APA: Copy

NOROOZZADEH, M., & RAMEZANI TEHRANI, F., & ZADEH VAKILI, A., & PIRYAEI, A., & GHASEMI, A., & AZIZI, F. (2016). THE EFFECTS OF TESTOSTERONE INTRAUTERINE DISTURBANCE ON SPERM QUALITY AND TESTIS TISSUE IN MALE RAT'S OFFSPRING AFTER PUBERTY. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(3 ), 372-384. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569983



Vancouver: Copy

NOROOZZADEH M., RAMEZANI TEHRANI F., ZADEH VAKILI A., PIRYAEI A., GHASEMI A., AZIZI F.. THE EFFECTS OF TESTOSTERONE INTRAUTERINE DISTURBANCE ON SPERM QUALITY AND TESTIS TISSUE IN MALE RAT'S OFFSPRING AFTER PUBERTY. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ). 2016 [cited 2021May11];19(3 ):372-384. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569983



IEEE: Copy

NOROOZZADEH, M., RAMEZANI TEHRANI, F., ZADEH VAKILI, A., PIRYAEI, A., GHASEMI, A., AZIZI, F., 2016. THE EFFECTS OF TESTOSTERONE INTRAUTERINE DISTURBANCE ON SPERM QUALITY AND TESTIS TISSUE IN MALE RAT'S OFFSPRING AFTER PUBERTY. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), [online] 19(3 ), pp.372-384. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569983.



 
 
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