Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   1ST WEEK DECEMBER 2017 , Volume 35 , Number 449 #A0032; Page(s) 1343 To 1351.
 
Paper: 

DEMOGRAPHIC, CLINICAL, AND FORENSICS FINDINGS IN DECEASED CASES OF ACUTE METHADONE POISONING

 
 
Author(s):  ALIKHANI BEHNAM, SOLEYMANPOUR ALI, SABZGHABAEE ALI MOHAMMAD, EIZADI MOOD NASTARAN*
 
* DEPARTMENT OF CLINICAL TOXICOLOGY, SCHOOL OF MEDICINE, ISFAHAN CLINICAL TOXICOLOGY RESEARCH CENTER, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Methadone is a common medication used for pain relief and addiction treatment. We evaluated clinical, demographic, and forensics findings in deceased cases of acute methadone poisoning.
Methods: An 11-year chart review study was done on deceased cases diagnosed with methadone poisoning admitted to a referral emergency ward affiliated to Isfahan University of Medical Sciences, Iran. Data were obtained through patients' records from 2005 to 2016 and analyzed using SPSS statistical software.
Findings: Of 81 deceased cases, 86.5% were men. The mean age of cases was 42.70
±19.22 years. The majority of men were 20-45 years old compared to less than 20 years old in women (P=0.005). Methadone abuse (55.6%) and suicide (35.8%) were the main causes of methadone poisoning in the deceased cases. Eighty two percent of cases had low consciousness on admission. Causes of poisoning, history of suicide, self-mutilation, smoking, and underlying diseases were significantly different in the various age groups. Respiratory failure as a mortality cause was recorded for the majority of cases (37.0%). Pathologic findings of liver and brain were recorded in 43.9% and 31.7% of cases, respectively. Multiorgan damages were noted in 42.6% of cases without any significant differences in the various age groups.
Conclusion: Given the prevalence of deceased cases due to methadone abuse at a young age, it is necessary to manage administration of methadone in different age groups to reduce mortality.

 
Keyword(s): METHADONE, POISONING, PATHOLOGY, AUTOPSY, MORTALITY
 
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