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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   4TH WEEK NOVEMBER 2017 , Volume 35 , Number 448 ; Page(s) 1263 To 1270.
 
Paper: 

THE EFFECT OF FOUR WEEKS OF AEROBIC SWIMMING ON THE LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND TYROSINE RECEPTOR KINASE B (TRKB) IN THE BRAIN OF ANIMAL MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALITIS (EAE)

 
 
Author(s):  SEYED ALHOSSEINI MEHDI*, RAJABI HAMID, GHADIRI ATAALLAH, GHARAKHANLOU REZA, SARKAKI ALIREZA
 
* DEPARTMENT OF EXERCISE PHYSIOLOGY, SCHOOL OF PHYSICAL EDUCATION AND SPORTS SCIENCES, KHARAZMI UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background: Multiple sclerosis (MS) is known as a neuroimmunological disease in human being. The evidences show that brain-derived neurotrophic factor (BDNF) and its specific receptor, tyrosine receptor kinase B (TrkB) play a role in the development of multiple sclerosis. Previous studies demonstrated that various interventions affect the expression of these factors. This study aimed to investigate the effect of four weeks of aerobic swimming on the level of BDNF and TrkB in the brain of mice with experimental autoimmune encephalomyelitis (EAE) or animal model of multiple sclerosis.
Methods: A total number of 80 C57BL/6 mice, aging 10 to 12 weeks and weighing 20
±2 gram were divided into eight groups of 10, control, swimming (SW), EAE, EAE+SW, EAE + solvent (SOL), EAE + interferon-beta (IFN), EAE + environment (En) +SOL, and EAE+SW+IFN. On post-immunization day 9, animals received IFN (150 IU/g) or were subjected to swimming daily for 4 weeks (5 days/ week). Brains were extracted and the levels of BDNF and TrkB were measured via enzyme-linked immunosorbent assay (ELISA). The data were analyzed using one-way ANOVA.
Findings: EAE decreased BDNF and increased TrkB level in the brain of EAE-induced mice. Level of BDNF and TrkB increased in mice brain following swimming and IFN treatment; however these alterations were not significant.
Conclusion: These findings suggest that probably swimming is more effective than IFN to alter the level of BDNF and TrkB in the brain of EAE-induced mice.

 
Keyword(s): EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, BRAIN-DERIVED NEUROTROPHIC FACTOR, TYROSINE RECEPTOR KINASE B (TRKB) RECEPTOR, SWIMMING
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

SEYED ALHOSSEINI, M., & RAJABI, H., & GHADIRI, A., & GHARAKHANLOU, R., & SARKAKI, A. (2017). THE EFFECT OF FOUR WEEKS OF AEROBIC SWIMMING ON THE LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND TYROSINE RECEPTOR KINASE B (TRKB) IN THE BRAIN OF ANIMAL MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALITIS (EAE). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(448 ), 1263-1270. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569857



Vancouver: Copy

SEYED ALHOSSEINI MEHDI, RAJABI HAMID, GHADIRI ATAALLAH, GHARAKHANLOU REZA, SARKAKI ALIREZA. THE EFFECT OF FOUR WEEKS OF AEROBIC SWIMMING ON THE LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND TYROSINE RECEPTOR KINASE B (TRKB) IN THE BRAIN OF ANIMAL MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALITIS (EAE). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2017 [cited 2021August04];35(448 ):1263-1270. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569857



IEEE: Copy

SEYED ALHOSSEINI, M., RAJABI, H., GHADIRI, A., GHARAKHANLOU, R., SARKAKI, A., 2017. THE EFFECT OF FOUR WEEKS OF AEROBIC SWIMMING ON THE LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND TYROSINE RECEPTOR KINASE B (TRKB) IN THE BRAIN OF ANIMAL MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALITIS (EAE). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 35(448 ), pp.1263-1270. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569857.



 
 
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