Paper Information

Journal:   JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES (JOURNAL OF HEALTH CHIMES)   WINTER 2018 , Volume 5 , Number 4 #R0038; Page(s) 61 To 71.
 
Paper: 

ASSESSING THE EFFECT OF DRUG TOLERANCE DUE TO CHRONIC ADMINISTRATION OF MORPHINE AND SALICYLATE ON SYNAPTIC PLASTICITY

 
 
Author(s):  GHOLAMI MASOUMEH*, SADEGH MEHDI
 
* NEUROSCIENCES RESEARCH CENTER, TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, TORBAT HEYDARIYEH, IRAN
 
Abstract: 

salicylate, morphine, drug tolerance, and synaptic plasticity. At the end, 62 of the obtained reports were included in the study.
Results: In addition to induction of tolerance to anti-nociceptive effect and cross-tolerance, chronic salicylate administration as like as morphine has long-lasting effects on hippocampal neuronal networks which are manifested as excitability of neurons and ability of activity and experience-dependent plasticity. Some of these effects can be documented in the hippocampus-related functions such as spatial learning and memory.
Conclusion: Considering the effects of salicylate and morphine on the nervous system and synaptic transmission, the effects of these drugs on the processing of input data and as a result on cognitive functioning would not be unlikely, thus necessitating further behavioral and electrophysiological studies.

 
Keyword(s): SALICYLATE, MORPHINE, DRUG TOLERANCE, SYNAPTIC PLASTICITY
 
References: 
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