salicylate, morphine, drug tolerance, and synaptic plasticity. At the end, 62 of the obtained reports were included in the study.
Results: In addition to induction of tolerance to anti-nociceptive effect and cross-tolerance, chronic salicylate administration as like as morphine has long-lasting effects on hippocampal neuronal networks which are manifested as excitability of neurons and ability of activity and experience-dependent plasticity. Some of these effects can be documented in the hippocampus-related functions such as spatial learning and memory.
Conclusion: Considering the effects of salicylate and morphine on the nervous system and synaptic transmission, the effects of these drugs on the processing of input data and as a result on cognitive functioning would not be unlikely, thus necessitating further behavioral and electrophysiological studies.