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Paper Information

Journal:   BIOLOGICAL JOURNAL OF MICROORGANISM   SUMMER 2017 , Volume 6 , Number 22 ; Page(s) 101 To 112.
 
Paper: 

EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS

 
 
Author(s):  MOAFI MOHAMMAD, REZVAN HOSSEIN*, SHERKAT ROYA, ZARKESH ESFAHANI SAYYED HAMID, TALEBAN ROYA, ASILIAN ALI, NILFOROUSHZADEH MOHAMMAD ALI, JAFFARY FARIBA, MANSOURIAN MARJAN, SOKHANVARI FATEMEH, ANSARI NAZLI
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY SCIENCE, BU-ALI SINA UNIVERSITY, HAMEDAN, IRAN
 
Abstract: 

Introduction: Different studies undertaken in the animal modeling show that Interferon-gamma deficiency impairs healing process of Leishmania infection. It seems that the level of Interferon-gamma production could also affect the healing duration of Leishmania lesion in humans. The current study aims to investigate the possibility of Interferon-gamma application for recognition of cases afflicted by non-healing Leishmaniasis.
Materials and methods: Peripheral blood mononuclear cells (PBMCs) of 32 patients, who were afflicted by healing or non-healing Leishmaniasis, were isolated and the levels of interferon-gamma were determined, using ELISA method. Afterwards, the cut-off point of interferon-gamma to identify patients afflicted by non-healing Leishmaniasis was calculated through ROC-Curve analysis. Furthermore, Leishmanin Skin Test (LST) was performed for every patient.
Results: Levels of Interferon-gamma produced by PBMCs stimulated with Soluble Leishmania Antigen (SLA) or Phytohemaglotinine were significantly higher in healing patients, compared with non-healing individuals (p <0.01). Interferon-gamma cut-off point in the optimized sensitivity (87.5%) and specificity (100%) was 1208 pg/ml. In addition, Levels of induration resulted from Lesihmanin Skin Test (LST) was significantly higher in healing patients, compared with healing individuals (p=0.023).
Discussion and conclusion: Interferon-gamma deficiency could be considered as one of the causative factors in non-healing Leishmaniasis in humans. In fact, Interferon-gamma deficiency can identify some patients afflicted by non-healing Leishmaniasis.

 
Keyword(s): CUTANEOUS LEISHMANIASIS, INTERFERON-GAMMA, LEISHMANIN
 
 
References: 
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Citations: 
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APA: Copy

MOAFI, M., & REZVAN, H., & SHERKAT, R., & ZARKESH ESFAHANI, S., & TALEBAN, R., & ASILIAN, A., & NILFOROUSHZADEH, M., & JAFFARY, F., & MANSOURIAN, M., & SOKHANVARI, F., & ANSARI, N. (2017). EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS. BIOLOGICAL JOURNAL OF MICROORGANISM, 6(22 ), 101-112. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569588



Vancouver: Copy

MOAFI MOHAMMAD, REZVAN HOSSEIN, SHERKAT ROYA, ZARKESH ESFAHANI SAYYED HAMID, TALEBAN ROYA, ASILIAN ALI, NILFOROUSHZADEH MOHAMMAD ALI, JAFFARY FARIBA, MANSOURIAN MARJAN, SOKHANVARI FATEMEH, ANSARI NAZLI. EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS. BIOLOGICAL JOURNAL OF MICROORGANISM. 2017 [cited 2021August02];6(22 ):101-112. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569588



IEEE: Copy

MOAFI, M., REZVAN, H., SHERKAT, R., ZARKESH ESFAHANI, S., TALEBAN, R., ASILIAN, A., NILFOROUSHZADEH, M., JAFFARY, F., MANSOURIAN, M., SOKHANVARI, F., ANSARI, N., 2017. EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS. BIOLOGICAL JOURNAL OF MICROORGANISM, [online] 6(22 ), pp.101-112. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569588.



 
 
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