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Paper Information

Journal:   INTERNATIONAL JOURNAL OF RADIATION RESEARCH   JULY 2016 , Volume 14 , Number 3; Page(s) 215 To 220.
 
Paper: 

SAFE DISTAL MARGIN RESECTION IN PATIENTS WITH LOW RECTAL CANCER UNDERGOING NEOADJUVANT CHEMORADIATION

 
 
Author(s):  GHAHRAMANI L., FOROOGHI M., MOHAMMADIANPANAH M., HOSSEINI S.V., IZADPANAH A., RAHIMIKAZEROONI S., GHAFARPASAND F., KHAZRAEI HAJAR*
 
* COLORECTAL RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Colorectal carcinoma is the third most common cause of death in Iran. This study was performed in order to determine the appropriate distal clearance margin (DCM) for resection of rectal cancer in patients who undergo neoadjuvant chemo radiotherapy for sphincter preserving procedure.
Materials and Methods: This was a cross-sectional study conducted in Shahid Faghihi Hospital of Shiraz University of Medical Sciences from 2006 to 2011. We included all patients with low rectal cancer who underwent neoadjuvant chemo radiotherapy. The medical charts of patients and disease characteristics were recorded. The local recurrence, recurrence-free survival and mortality rates were compared between those with DCM ?2cm and DCM<2cm.
Results: Overall, 82 patients with a mean age of 56.7±16.4 years were included. The DCM was found to be ?2cm in 45 (54.9%) patients and<2cm in 37 (45.1%). The two study groups were comparable in terms of age (p=0.573), sex (p=0.505), histopathological tumor grade (p=0.165), and distance of tumor to anal verge (p=0.125). Patients with DCM ?2cm had a lower local recurrence rate (35.6% vs.97.3%; p<0.001), a higher recurrence-free survival rate (88.9% vs.67.6%; p=0.032) and a lower mortality rate (11.1% vs.32.4%; p=0.027).
Conclusion: Although some studies have showed that DCM<2cm leads to similar results compared to DCM? 2cm, our findings revealed that obtaining a distal clearance margin of 2cm for resection of rectal cancer in patients who have undergone neo-adjuvant chemo radiotherapy is associated with a lower local recurrence rate, higher recurrence-free survival rate and lower mortality rate.

 
Keyword(s): RECTAL CANCER, LOW ANTERIOR RESECTION (LAR), CHEMO RADIOTHERAPY (CRM), DISTAL CLEARANCE MARGIN (DCM), LOCAL RECURRENCE
 
 
References: 
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Citations: 
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APA: Copy

GHAHRAMANI, L., & FOROOGHI, M., & MOHAMMADIANPANAH, M., & HOSSEINI, S., & IZADPANAH, A., & RAHIMIKAZEROONI, S., & GHAFARPASAND, F., & KHAZRAEI, H. (2016). SAFE DISTAL MARGIN RESECTION IN PATIENTS WITH LOW RECTAL CANCER UNDERGOING NEOADJUVANT CHEMORADIATION. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 14(3), 215-220. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569586



Vancouver: Copy

GHAHRAMANI L., FOROOGHI M., MOHAMMADIANPANAH M., HOSSEINI S.V., IZADPANAH A., RAHIMIKAZEROONI S., GHAFARPASAND F., KHAZRAEI HAJAR. SAFE DISTAL MARGIN RESECTION IN PATIENTS WITH LOW RECTAL CANCER UNDERGOING NEOADJUVANT CHEMORADIATION. INTERNATIONAL JOURNAL OF RADIATION RESEARCH. 2016 [cited 2021September28];14(3):215-220. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569586



IEEE: Copy

GHAHRAMANI, L., FOROOGHI, M., MOHAMMADIANPANAH, M., HOSSEINI, S., IZADPANAH, A., RAHIMIKAZEROONI, S., GHAFARPASAND, F., KHAZRAEI, H., 2016. SAFE DISTAL MARGIN RESECTION IN PATIENTS WITH LOW RECTAL CANCER UNDERGOING NEOADJUVANT CHEMORADIATION. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, [online] 14(3), pp.215-220. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569586.



 
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