Paper Information

Journal:   INTERNATIONAL JOURNAL OF RADIATION RESEARCH   JULY 2016 , Volume 14 , Number 3; Page(s) 205 To 213.
 
Paper: 

EFFECTS OF PROBIOTICS WITH OR WITHOUT HONEY ON RADIATION-INDUCED DIARRHEA

 
 
Author(s):  MANSOURI TEHRANI H.S., RABBANI KHORASGANI M., ROAYAEI MAHNAZ*
 
* DEPARTMENT OF RADIATION ONCOLOGY, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The present study evaluated the effects of probiotic with or without honey on radiation-induced diarrhea.
Materials and Methods: Sixty-seven adult patients with pelvic cancer underwent radiotherapy for four weeks. They randomized to receive probiotic (n=22), probiotic plus honey (n=21) or placebo (n=24) from one week before radiotherapy for five weeks. Diarrhea grade and stool consistency score were recorded weekly according to the Common Toxicity Criteria system and the Bristol scales, respectively.
Results: The results showed a decrease in the daily number of bowel movements (p=0.003 and 0.006), diarrhea grade (p=0.001 and 0.001) and the need for antidiarrheal medication (p=0.021 and 0.041) also an increase in the stool consistency (p=0.004 and 0.005) in patients who either used probiotic or probiotic plus honey (respectively), these were significant in weeks 4 and 5 of treatment.
Conclusion: Probiotics with or without honey can reduce the incidence of radiation-induced diarrhea and the need for antidiarrheal medication.

 
Keyword(s): PROBIOTICS, HONEY, DIARRHEA, RADIOTHERAPY, PELVIC CANCER
 
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