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Paper Information

Journal:   IRANIAN JOURNAL OF VIROLOGY   2015 , Volume 9 , Number 2; Page(s) 14 To 19.
 
Paper: 

HHV-6 DNA AND ANTIBODY DETECTION IN PLASMA AND PBMC OF MULTIPLE SCLEROSIS PATIENTS IN NORTH OF IRAN

 
 
Author(s):  AHMADI A., NAEIMI M.H., JAVID N., MORADI A., VAKILI M.A., TABARRAEI A.*
 
* PHD; INFECTIOUS DISEASES RESEARCH CENTER, DEPARTMENT OF MICROBIOLOGY, GOLESTAN UNIVERSITY OF MEDICAL SCIENCES, GORGAN, IRAN
 
Abstract: 

Background and Aims: Multiple sclerosis (MS) is defined by the presence of inflammatory demyelinating plaques in the central nervous system (CNS). It has been indicated that human herpes virus 6 (HHV-6) may play role in pathogenesis of MS. The aim of this study was to determine the presence of HHV-6 DNA and anti HHV-6 IgG in MS patients and controls.
Materials and Methods: Blood samples from 59 patients with MS and 59 healthy controls were collected. DNA extraction and real-time PCR based on (Syber Green) were done in the peripheral blood mononuclear cells (PBMCs) and in plasma specimens. Anti-HHV-6 IgG was measured by ELISA technique. Demographic and clinical data were collected and entered in SPSS 16 and analyzed.
Results: HHV-6 DNA was found in the plasma sample of 1 (1.7%) of 59 MS patients. There was no HHV-6 DNA in PBMCs of the MS patients and controls and in plasma of control group. Anti- HHV-6 IgG antibody was present in 84.7% of MS patients and 82.1% of control group.
Conclusion: There was no significant relation based on presence of HHV-6 DNA and antibody between MS patients and controls in north of Iran.

 
Keyword(s): HHV-6, MULTIPLE SCLEROSIS, REAL-TIME PCR, ELISA
 
 
References: 
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Click to Cite.
APA: Copy

AHMADI, A., & NAEIMI, M., & JAVID, N., & MORADI, A., & VAKILI, M., & TABARRAEI, A. (2015). HHV-6 DNA AND ANTIBODY DETECTION IN PLASMA AND PBMC OF MULTIPLE SCLEROSIS PATIENTS IN NORTH OF IRAN. IRANIAN JOURNAL OF VIROLOGY, 9(2), 14-19. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569512



Vancouver: Copy

AHMADI A., NAEIMI M.H., JAVID N., MORADI A., VAKILI M.A., TABARRAEI A.. HHV-6 DNA AND ANTIBODY DETECTION IN PLASMA AND PBMC OF MULTIPLE SCLEROSIS PATIENTS IN NORTH OF IRAN. IRANIAN JOURNAL OF VIROLOGY. 2015 [cited 2021May12];9(2):14-19. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569512



IEEE: Copy

AHMADI, A., NAEIMI, M., JAVID, N., MORADI, A., VAKILI, M., TABARRAEI, A., 2015. HHV-6 DNA AND ANTIBODY DETECTION IN PLASMA AND PBMC OF MULTIPLE SCLEROSIS PATIENTS IN NORTH OF IRAN. IRANIAN JOURNAL OF VIROLOGY, [online] 9(2), pp.14-19. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569512.



 
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