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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   3RD WEEK NOVEMBER 2017 , Volume 35 , Number 447 ; Page(s) 1249 To 1255.
 
Paper: 

EVALUATION OF THE EFFECTS OF TWO DIFFERENT DOSES OF MIDODRINE ALPHA- AGONIST ON PREVENTION OF VASOPLEGIA CAUSED BY CARDIOPULMONARY BYPASS PUMP

 
 
Author(s):  MANSOURI MOJTABA, ESMAEILZADEH MARYAM*, MASSOMI GHOLAMREZA
 
* STUDENT RESEARCH COMMITTEE, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Vasoplegia or vasoplegic syndrome is a type of vasodilator shock that occurs in a large number of patients after cardiac surgery under a cardiac pulmonary pump, which can increase the incidence of complications and mortality in patients. Therefore, it is necessary to find a way to treat this disease. So, the aim of this study was to evaluate the effect of two doses of alpha- agonist midodrine on the prevention of vasoplegic syndrome induced by cardiopulmonary bypass.
Methods: This study was performed on 135 patients undergoing cardiac surgery (45 cases in midodrine 5 mg, 45 cases in midodrine 10 mg, and 45 cases in control group) in Chamran hospital, Isfahan, Iran, in 2016. Patients were randomly assigned into three groups, the drugs were prescribed one hour before surgery, and the vital sign and complications were recorded in patients. Chi- square and ANOVA tests were used to compare the data.
Findings: The mean blood pressure during the pump was higher in the midodrine 10 mg group than the other groups (5 mg midodrine and control) (P=0.021); and the mean ephedrine administration in this group (15.33 mg) was also less than 5 mg midodrine (21.55 mg) and control (29.77 mg) groups (P=0.122).
Conclusion: Considering the high incidence of vasoplegic syndrome after cardiac surgery, administrating 10 mg of midodrine can improve clinical symptoms during the pump and reduce the need for vasopressor drugs, which can make better surgical results.

 
Keyword(s): VASOPLEGIA, CARDIOPULMONARY BYPASS, MIDODRINE
 
 
References: 
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Click to Cite.
APA: Copy

MANSOURI, M., & ESMAEILZADEH, M., & MASSOMI, G. (2017). EVALUATION OF THE EFFECTS OF TWO DIFFERENT DOSES OF MIDODRINE ALPHA- AGONIST ON PREVENTION OF VASOPLEGIA CAUSED BY CARDIOPULMONARY BYPASS PUMP. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(447 ), 1249-1255. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569363



Vancouver: Copy

MANSOURI MOJTABA, ESMAEILZADEH MARYAM, MASSOMI GHOLAMREZA. EVALUATION OF THE EFFECTS OF TWO DIFFERENT DOSES OF MIDODRINE ALPHA- AGONIST ON PREVENTION OF VASOPLEGIA CAUSED BY CARDIOPULMONARY BYPASS PUMP. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2017 [cited 2021May13];35(447 ):1249-1255. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569363



IEEE: Copy

MANSOURI, M., ESMAEILZADEH, M., MASSOMI, G., 2017. EVALUATION OF THE EFFECTS OF TWO DIFFERENT DOSES OF MIDODRINE ALPHA- AGONIST ON PREVENTION OF VASOPLEGIA CAUSED BY CARDIOPULMONARY BYPASS PUMP. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 35(447 ), pp.1249-1255. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569363.



 
 
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