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Paper Information

Journal:   IRANIAN JOURNAL OF RADIOLOGY   JULY 2016 , Volume 13 , Number 3; Page(s) 0 To 0.
 
Paper: 

CHANGES OF T2 RELAXATION TIME FROM NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER LESIONS

 
 
Author(s):  LIU LI, YIN BO, GENG DAO YING, LU YI PING, PENG WEI JUN*
 
* DEPARTMENT OF RADIOLOGY, SHANGHAI CANCER CENTER, FUDAN UNIVERSITY, SHANGHAI, CHINA
 
Abstract: 

Background: Neoadjuvant chemotherapy (NAC) is generally an effective method of reducing locally advanced malignant breast lesions before surgery; assessing the tumor response to NAC is crucial for patient management. T2 relaxation times can reflect biological state of lesions, may prove useful to assess the response to NAC.
Objectives: To investigate the lesion T2 relaxation times change in breast cancer neoadjuvant chemotherapy (NAC).
Patients and Methods: In total, 26 patients underwent NAC. Magnetic resonance imaging (MRI) T2 mapping was performed before and after NAC. The T2 relaxation times were obtained by using Functool software on an AW43 workstation. The treatment response was assessed according to the pathological response classification. Weaimedto analyze the changes in the T2 relaxation times before and after NAC as well as to study the relationship between the response and the lesion T2 relaxation times after NAC.
Results: In 26 cases with NAC, the mean lesion T2 relaxation time before NAC was 81.34
±13.68 ms, compared with 64.50±8.71 ms after NAC. Significant differences in the lesion T2 relaxation times existed between the pre- and post-NAC (P<0.001) ; based on the pathology results, the mean lesion T2 relaxation times in 23 of the 26 responders (63.18±8.37 ms) was shorter than in 3 of the 26 nonresponders (74.62±2.32 ms) after NAC (P=0.029).
Conclusion: In breast cancer after NAC, the lesion T2 relaxation time was reduced in the responders, and this finding is potentially useful to assess the response to NAC.

 
Keyword(s): BREAST NEOPLASMS, MRI, T2 RELAXOMETRY
 
 
References: 
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Click to Cite.
APA: Copy

LIU, L., & YIN, B., & GENG, D., & LU, Y., & PENG, W. (2016). CHANGES OF T2 RELAXATION TIME FROM NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER LESIONS. IRANIAN JOURNAL OF RADIOLOGY, 13(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569341



Vancouver: Copy

LIU LI, YIN BO, GENG DAO YING, LU YI PING, PENG WEI JUN. CHANGES OF T2 RELAXATION TIME FROM NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER LESIONS. IRANIAN JOURNAL OF RADIOLOGY. 2016 [cited 2021May12];13(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569341



IEEE: Copy

LIU, L., YIN, B., GENG, D., LU, Y., PENG, W., 2016. CHANGES OF T2 RELAXATION TIME FROM NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER LESIONS. IRANIAN JOURNAL OF RADIOLOGY, [online] 13(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569341.



 
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