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Paper Information

Journal:   NOVELTY IN BIOMEDICINE   2016 , Volume 4 , Number 1; Page(s) 5 To 12.
 
Paper: 

DIAGNOSTIC PERFORMANCE OF F-18 FDG PET/CT IN PATIENTS WITH CANCER OF UNKNOWN PRIMARY: ADDITIONAL BENEFIT OVER CT-BASED CONVENTIONAL WORK UP

 
 
Author(s):  BAKHSHAYESHKARAM MEHRDAD, GHOBADI MOHSEN, HASSANZAD MARYAM, DOROUDINIA ABTIN, JAMAATI HAMID REZA, AGHAHOSSEINI FARAHNAZ*
 
* NATIONAL RESEARCH INSTITUTE OF TUBERCULOSIS AND LUNG DISEASE (NRITLD), MASSIH DANESHVARI HOSPITAL. DAAR-ABAD, NIAVARAN AVE., TEHRAN, IRAN. ZIP CODE: 19569-44413
 
Abstract: 

Background: In the era of well-developed site-specific treatment strategies in cancer, identification of occult primary is of paramount importance in CUP patients. Furthermore, exact determination of the extent of the disease may help in optimizing treatment planning. The aim of the present study was to investigate additional value of F-18 FDG PET/CT in patients with cancer of unknown primary (CUP) as an appropriate imaging tool in early phase of initial standard work up.
Materials and Methods: Sixty-two newly diagnosed CUP patients with inconclusive diagnostic CT scan of chest, abdomen and pelvis referring for F-18 FDG PET/CT were enrolled in this study. Standard of reference was defined as histopathology, other diagnostic procedures and a 3-month formal clinical follow up. The results of PET/CT were categorized as suggestion for primary site and additional metastasis and classified as true positive, false positive, false negative and true negative. The impact of additional metastasis revealed by F-18 FDG PET/CT on treatment planning and the time contribution of F-18 FDG PET/CT in diagnostic pathway was investigated.
Results: Sixty-two patients with mean age of 62 (30 men, 32 women), PET/CT correctly identified primary origin in 32% with false positive rate of 14.8%. No primary lesion was detected after negative PET/CT according to standard of reference. Sensitivity, Specificity and accuracy were 100%, 78% and 85%, respectively. Additional metastatic site was found in 56% with 22% impact on treatment planning. Time contribution for PET/CT was 10% of total diagnostic pathway.
Conclusion: Providing higher detection rate of primary origin with excellent diagnostic performance, shortening the diagnostic pathway and improving treatment planning, F-18 FDG PET/CT may play a major role in diagnostic work up of CUP patients and may be recommended as an alternative imaging tool in early phase of investigation.

 
Keyword(s): F-18 FDG PET/CT, CANCER OF UNKNOWN PRIMARY, DIAGNOSTIC PERFORMANCE
 
 
References: 
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Click to Cite.
APA: Copy

BAKHSHAYESHKARAM, M., & GHOBADI, M., & HASSANZAD, M., & DOROUDINIA, A., & JAMAATI, H., & AGHAHOSSEINI, F. (2016). DIAGNOSTIC PERFORMANCE OF F-18 FDG PET/CT IN PATIENTS WITH CANCER OF UNKNOWN PRIMARY: ADDITIONAL BENEFIT OVER CT-BASED CONVENTIONAL WORK UP. NOVELTY IN BIOMEDICINE, 4(1), 5-12. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569301



Vancouver: Copy

BAKHSHAYESHKARAM MEHRDAD, GHOBADI MOHSEN, HASSANZAD MARYAM, DOROUDINIA ABTIN, JAMAATI HAMID REZA, AGHAHOSSEINI FARAHNAZ. DIAGNOSTIC PERFORMANCE OF F-18 FDG PET/CT IN PATIENTS WITH CANCER OF UNKNOWN PRIMARY: ADDITIONAL BENEFIT OVER CT-BASED CONVENTIONAL WORK UP. NOVELTY IN BIOMEDICINE. 2016 [cited 2021May15];4(1):5-12. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569301



IEEE: Copy

BAKHSHAYESHKARAM, M., GHOBADI, M., HASSANZAD, M., DOROUDINIA, A., JAMAATI, H., AGHAHOSSEINI, F., 2016. DIAGNOSTIC PERFORMANCE OF F-18 FDG PET/CT IN PATIENTS WITH CANCER OF UNKNOWN PRIMARY: ADDITIONAL BENEFIT OVER CT-BASED CONVENTIONAL WORK UP. NOVELTY IN BIOMEDICINE, [online] 4(1), pp.5-12. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569301.



 
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