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Paper Information

Journal:   JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES (JOURNAL OF HEALTH CHIMES)   FALL 2017 , Volume 5 , Number 3 ; Page(s) 39 To 47.
 
Paper: 

COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS

 
 
Author(s):  MOSAFER JAFAR*, BAZRAFSHAN EDRIS
 
* NANOTECHNOLOGY RESEARCH CENTER, SCHOOL OF PHARMACY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Background and Aim: The aim of this study was to compare the effects of hydro-alcoholic extract of Curcuma longa (C.L E) and Nigella sativa (N.S E) with Vitamin C on renal-oxidative damage in rats.
Methods: 40 male Wistar rats were randomly divided into five groups (n=8) as follows: A Control group with plain drinking water and intervention groups including positive control groups with Vitamin C (100 mg/kg), the N.S E (200 mg/kg) group, the C.L E (1000 mg/kg) group and N.S E and C.L E group (receiving 200 and 1000 mg/kg, respectively), all dissolved in drinking water and fed during the 35 days of the experiment. At the end of this period, the renal tissues were removed and oxidation-reduction markers were investigated.
Results: N.S E (P<0.001), C.L E and vitamin C (P<0.01) decreased serum creatinine and BUN levels in comparison to the control group. Not only were the levels of total thiol higher in the Vitamin C (P<0.001), N.S E, C.L E (P<0.05) and N.S E and C.L E (P<0.01) groups compared to the control group, but also the superoxide dismutase (SOD) activity was more elevated in Vitamin C and N.S E and C.L E groups (P<0.01). Malondialdehyde (MDA) concentrations in the N.S E and C.L E, N.S E (P<0.001) and Vitamin C (P<0.05) groups were lower than those in the control group.
Conclusion: In the current study, it was found that N.S E and C.L E have a significant effect on the improvement of renal oxidative stress, which is comparable to Vitamin C. A higher synergistic effect of N.S E and C.L E suggested that they are more effective combined than when used separately.

 
Keyword(s): NIGELLA SATIVA, CURCUMA LONGA, VITAMIN C, OXIDATIVE STRESS
 
 
References: 
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APA: Copy

MOSAFER, J., & BAZRAFSHAN, E. (2017). COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES (JOURNAL OF HEALTH CHIMES), 5(3 ), 39-47. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569295



Vancouver: Copy

MOSAFER JAFAR, BAZRAFSHAN EDRIS. COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES (JOURNAL OF HEALTH CHIMES). 2017 [cited 2021May09];5(3 ):39-47. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569295



IEEE: Copy

MOSAFER, J., BAZRAFSHAN, E., 2017. COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES (JOURNAL OF HEALTH CHIMES), [online] 5(3 ), pp.39-47. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569295.



 
 
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