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Paper Information

Journal:   JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES   FALL 2017 , Volume 5 , Number 3 ; Page(s) 17 To 25.
 
Paper: 

THE FREQUENCY OF BLA PER , BLA VEB , BLA CTX-M , TETA AND TETB GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZES PATIENTS IN TEHRAN

 
 
Author(s):  AZIZI OMID*, SHAHCHERAGHI FERESHTEH
 
* DEPARTMENT OF BACTERIOLOGY, MICROBIOLOGY RESEARCH CENTER, PASTEUR INSTITUTE OF IRAN, TEHRAN, IRAN
 
Abstract: 

Background & Aim: Infections and outbreaks caused by multidrug-resistant Acinetobacter baumannii are prevalent and have been reported worldwide over the past twenty or more years. Beta-lactamase genes including bla PER, bla VEB and bla CTX-M confer resistance to beta-lactam antibiotics and tetA and tetB are responsible for resistance to tetracycline in such bacteria.
Methods: A total of 65 isolates of A. Baumannii from clinical samples were collected. Antimicrobial susceptibility testing was performed by the disk diffusion method according to the CLSI guideline and the presence of bla OXA-51 tet A, tet B, bla VEB, bla CTX and bla PER were screened via the polymerase chain reaction (PCR).
Results: The isolates were 100% resistant to gentamicin, ciprofloxacin, piperacillin, cefotaxime, ceftazidime and tetracycline. Resistance to minocycline and imipenem stood at 89% and 85%, respectively. All isolates were identified as multi-drug resistant (MDR). The genes tet A, tet B, bla VEB, bla CTX and bla PER were detected in 75.3%, 43%, 35.3%, 76.9% and 61.5% of isolates, respectively.
Conclusion: This study revealed the high prevalence of antimicrobial resistance genes amongst Acinetobacter baumannii and thus con?rms the need for isolating and identifying them in clinical laboratory and hospital settings.

 
Keyword(s): ACINETOBACTER, ANTIBIOTIC RESISTANCE, BETA-LACTAMASE
 
 
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Citations: 
 
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APA: Copy

AZIZI, O., & SHAHCHERAGHI, F. (2017). THE FREQUENCY OF BLA PER , BLA VEB , BLA CTX-M , TETA AND TETB GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZES PATIENTS IN TEHRAN. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 5(3 ), 17-25. https://www.sid.ir/en/journal/ViewPaper.aspx?id=569284



Vancouver: Copy

AZIZI OMID, SHAHCHERAGHI FERESHTEH. THE FREQUENCY OF BLA PER , BLA VEB , BLA CTX-M , TETA AND TETB GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZES PATIENTS IN TEHRAN. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES. 2017 [cited 2021July26];5(3 ):17-25. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569284



IEEE: Copy

AZIZI, O., SHAHCHERAGHI, F., 2017. THE FREQUENCY OF BLA PER , BLA VEB , BLA CTX-M , TETA AND TETB GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZES PATIENTS IN TEHRAN. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, [online] 5(3 ), pp.17-25. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=569284.



 
 
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