Cheshtiyeh, connected to Chesht Sheikh (suge), is the name of a Suffism dynasty. Chesht is a region in Herat, Khorasan. The founder of this dynasty is Khaje Abu Ahmad Abdal Cheshti (born in A.H.260). The family tree of Cheshtiyeh dynasty is related to Imam Baqer, Hazrate Ali and Prophet Muhammad, through Ibrahim Adham. The followers of this suffism dynesty follow Hanifi sect. Cheshtiyeh played an important role in reviving the cultural and social life first in Khorasan and then in India. The purpose of the current study is to examine the historical development, Cheshtiyeh from its inception to the end of its climax period. To achieve this, descriptive, analytical and field procedures were used. Specifically, the current research is aimd at answering the following question: What is the role of Cheshtiyeh in social, cultural and political developments of Islamic world particulary Khorasan and India, and how Cheshtiyeh was affected by those development? The research hypothesis is that Cheshtiyeh Sufism played an important role in spreading Islamic- Iranian culture and civilization in the Islamic world especially in India. Moreover, Cheshtiyeh Sufism was greatly influenced by the cultural context of India.