Islamic mysticism and Sufism one of the significant issues of social and cultural studies Sistan and Khorasan in the early centuries of Islam. This intellectual and social movement since the beginning of the first century, by asceticism and escape from worldly pleasures began in the Muslim world and in the next century Yafth Tr organization in East Iran, and many fans had obtained. Several factors such as the presence of Hassan Basri and his followers, Sufi Kramyh, Malamatia and in the development of mystical thought was effective in Sistan and Khorasan. In this article, it is up to the style library, Information and historical data collection and analytical method to investigate the causes of the spread of mysticism in Sistan and mutual influence on each other mystics and Sufis al-Sistani and Khorasani be addressed. Mysticism and Sufism in the third and fourth centuries achievements have positive and beneficial for local people to have And the religious fanaticism among the Khawarij and Sunni Hanafi and Shafei, murder and Gharthay with it in the past was due to the decrease.