Paper Information

Journal:   FEYZ   AUGUST 2016 , Volume 20 , Number 3 #A0027; Page(s) 274 To 281.
 
Paper: 

DETERMINATION OF HEPATITIS B SURFACE ANTIBODY AND GAMMA INTERFERON RESPONSIVENESS IN VACCINATED PERSONNEL REFFERED TO A HEALTH NETWORK IN DASHTE-E AZADEGAN (KHOZESTAN PROVINCE)

 
 
Author(s):  HEIDARI S., REZATOFIGHI S.E.*, ROAYAEI ARDAKANI M., AKHOND M.R.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, SHAHID CHAMRAN UNIVERSITY OF AHVAZ, AHVAZ, I.R. IRAN
 
Abstract: 

Background: Among the preventing measures for hepatitis B is vaccination against the virus. This study aimed to determine the antibody level against the hepatitis B surface antigen (anti-HBs) and its relation to interferon gamma (IFN-g) level among the vaccinated staffs and also the reasons for the lack of response in such persons.
Materials and Methods: This cross-sectional study was done on vaccinated staff (n=130) referred to Shahid Chamran Hospital. Using ELISA the samples were studied for anti-HBsAb and INF-
g level. Then, the relationship between antibody level and some indexes (e.g. sex, age, BMI, number of vaccine doses, time past after the last dose and INF-g level) was considered.
Results: Among the studied participants, 68.5% and 31.5% had a perfect and failure of immunity response (>10 IU/ml and<10 IU/ml, respectively). There was a direct relationship between the INF-
g and anti-HBs titration (R=0.635). In addition, there was a significant relationship (P<0.05) between anti-HBs titer and some indexes (e.g. BMI, the number of doses and the time interval since the last dose of vaccine); however, no significant relationship was observed between the sex and age on one hand and antibody titration on the other hand.
Conclusion: Failure in INF-
g production against the virus can have a role in immunity response. Hence, measuring the anti-HBs level following the vaccination and also 5 years after are suggested for high risk cases; then, upon which a decision can be made on the reminder dosage.

 
Keyword(s): HEPATITIS B, VACCINATION, GAMMA INTERFERON, ANTIBODY, PERSONNEL
 
References: 
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