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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   2ND WEEK NOVEMBER 2017 , Volume 35 , Number 446 ; Page(s) 1185 To 1191.
 
Paper: 

EVALUATION OF THE EFFECTS OF VITAMIN E ON PREMATURITY COMPLICATIONS IN PREMATURE NEONATES

 
 
Author(s):  BAREKATAIN BEHZAD, ARMANIAN AMIR MOHAMMAD, FARGHADANI MARYAM, SAFAEI ALI*, SHAHSANAI ARMINDOKHT, SARAEIAN SAMIRA
 
* STUDENT RESEARCH COMMITTEE, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Prematurity is accompanied with various complications including sepsis, necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and apnea. In current study, we assessed the effects of oral vitamin E on incidence of prematurity complications in premature neonates.
Methods: This was a clinical trial study on 76 neonates in Alzahra hospital, Isfahan, Iran, during 2015-2017. Neonates were randomly divided in two age- and sex-matched group.38 neonates of case group were treated with 10 units of vitamin E through orogastric tube for three days. Control group were treated with distilled water through orogastric tube. Patients in two groups were evaluated in terms of sepsis, NEC and IVH.
Findings: In this study, 48.7% of patients were boys. Mean neonates' age and weight was 28.49 ± 1.46 weeks and 1183.02 ± 167.97 g, respectively. Incidence of sepsis (P=0.77), NEC (P=0.53), hypotension (P=0.31), death (P=0.45), and IVH in 4th (P=0.30) and 7th (P=0.20) day of birth was not significantly different between the two groups.
Conclusion: Using oral vitamin E did not have statistically significant effect on prevention of sepsis, necrotizing enterocolitis, and intraventricular hemorrhage. Due to more controllable bioavailability of oral vitamin E in comparison to intramuscular and intravenous use of it, and increased risk of sepsis and necrotizing enterocolitis by using high doses of vitamin E in other reports, further studies with different doses of oral vitamin E are recommended.

 
Keyword(s): PRETERM LABOR, SEPSIS, NECROTIZING ENTEROCOLITIS, HEMORRHAGE, PREVENTION
 
 
References: 
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APA: Copy

BAREKATAIN, B., & ARMANIAN, A., & FARGHADANI, M., & SAFAEI, A., & SHAHSANAI, A., & SARAEIAN, S. (2017). EVALUATION OF THE EFFECTS OF VITAMIN E ON PREMATURITY COMPLICATIONS IN PREMATURE NEONATES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(446 ), 1185-1191. https://www.sid.ir/en/journal/ViewPaper.aspx?id=568769



Vancouver: Copy

BAREKATAIN BEHZAD, ARMANIAN AMIR MOHAMMAD, FARGHADANI MARYAM, SAFAEI ALI, SHAHSANAI ARMINDOKHT, SARAEIAN SAMIRA. EVALUATION OF THE EFFECTS OF VITAMIN E ON PREMATURITY COMPLICATIONS IN PREMATURE NEONATES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2017 [cited 2021May16];35(446 ):1185-1191. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568769



IEEE: Copy

BAREKATAIN, B., ARMANIAN, A., FARGHADANI, M., SAFAEI, A., SHAHSANAI, A., SARAEIAN, S., 2017. EVALUATION OF THE EFFECTS OF VITAMIN E ON PREMATURITY COMPLICATIONS IN PREMATURE NEONATES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 35(446 ), pp.1185-1191. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568769.



 
 
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