Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   4TH WEEK OCTOBER 2017 , Volume 35 , Number 444 ; Page(s) 1113 To 1119.
 
Paper: 

PREVALENCE STUDY OF EXTENDED SPECTRUM BETA-LACTAMASE IN KLEBSIELLA PNEUMONIA ISOLATED FROM PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN KERMANSHAH CITY, IRAN

 
 
Author(s):  VAZIRI SIAVASH, MANSOURI FAIZULLAH, ABIRI RAMIN, ALVANDI AMIRHOOSHANG, MORTAZAVI SEYED HAMIDREZA, AHMADI KAMAL, MIRZAEI MARYAM, AZIZI MOHSEN*
 
* DEPARTMENT OF MICROBIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Background: One of the most common infections in patients with high mortality rate is ventilator-dependent pneumonia. This study aimed to determine the frequency of extended spectrum beta-lactamase (ESBL) in Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia in Kermanshah City, Iran.
Methods: This study performed on tracheal tube samples of patients admitted to the intensive care units. After collecting specimens, 57 Klebsiella pneumonia isolates were confirmed via standard bacteriological and biochemical tests. After antibiotic susceptibility testing by using disk diffusion method, the presence of ESBL phenotype was determined via combined disk test. The frequency of ESBL genes was determined by using their specific primers and polymerase chain reaction (PCR) method. Findings: From 57 isolates of Klebsiella pneumonia, 22 (38.6%) were positive for ESBL, phenotypically. The highest genotype frequency was shv gene (31.6%) determined via PCR test. The highest resistance was to ceftriaxone and co-trimoxazole (78.9%), and the lowest resistance was to colistin (3.5%).
Conclusion: Considering the high resistance of Klebsiella isolated from samples of patients with ventilator- associated pneumonia against third-generation cephalosporin and the prevalence of ESBL-producing strains among these patients, identification of isolates with ESBL and suitable antibiotic selection for the treatment of this patients seem to be necessary.

 
Keyword(s): VENTILATOR-ASSOCIATED PNEUMONIA, ANTIBACTERIAL DRUG RESISTANCE, INTENSIVE CARE UNIT
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

VAZIRI, S., & MANSOURI, F., & ABIRI, R., & ALVANDI, A., & MORTAZAVI, S., & AHMADI, K., & MIRZAEI, M., & AZIZI, M. (2017). PREVALENCE STUDY OF EXTENDED SPECTRUM BETA-LACTAMASE IN KLEBSIELLA PNEUMONIA ISOLATED FROM PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN KERMANSHAH CITY, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(444 ), 1113-1119. https://www.sid.ir/en/journal/ViewPaper.aspx?id=568601



Vancouver: Copy

VAZIRI SIAVASH, MANSOURI FAIZULLAH, ABIRI RAMIN, ALVANDI AMIRHOOSHANG, MORTAZAVI SEYED HAMIDREZA, AHMADI KAMAL, MIRZAEI MARYAM, AZIZI MOHSEN. PREVALENCE STUDY OF EXTENDED SPECTRUM BETA-LACTAMASE IN KLEBSIELLA PNEUMONIA ISOLATED FROM PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN KERMANSHAH CITY, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2017 [cited 2021July29];35(444 ):1113-1119. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568601



IEEE: Copy

VAZIRI, S., MANSOURI, F., ABIRI, R., ALVANDI, A., MORTAZAVI, S., AHMADI, K., MIRZAEI, M., AZIZI, M., 2017. PREVALENCE STUDY OF EXTENDED SPECTRUM BETA-LACTAMASE IN KLEBSIELLA PNEUMONIA ISOLATED FROM PATIENTS WITH VENTILATOR-ASSOCIATED PNEUMONIA IN KERMANSHAH CITY, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 35(444 ), pp.1113-1119. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568601.



 
 
Persian Abstract Yearly Visit 45
 
 
Latest on Blog
Enter SID Blog