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| Journal:
JOURNAL OF REPRODUCTION AND INFERTILITY
2017
, Volume 18
, Number 3; Page(s)
307
To
315. |
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| Paper:
Y Chromosome Microdeletions In Infertile Men With Non-Obstructive Azoospermia And Severe Oligozoospermia
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| Author(s):
Kim Shin Young, Kim Hyun Jin, Lee Bom Yi, Park So Yeon, Lee Hyo Serk, Seo Ju Tae*
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| * DEPARTMENT OF UROLOGY, CHEIL GENERAL HOSPITAL AND WOMEN' S HEALTHCARE CENTER, DANKOOK UNIVERSITY COLLEGE OF MEDICINE, 1-19 MUKJEONG-DONG, JUNG-GU, SEOUL, KOREA, ZIP CODE: 100-380 |
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| Abstract:
Background: The purpose of the study was to investigate the frequencies and types of Y chromosome microdeletions in infertile men and to analyze the relationship between the levels of reproductive hormones and Y microdeletions.Methods: A total of 1, 226 infertile men were screened for Y chromosome microdeletions using multiplex PCR assay. Karyotype analysis was performed on peripheral blood lymphocytes with standard G-banding. Serum reproductive hormone levels were measured.Results: Out of 1, 226 infertile patients, 134 (10.93%) had Y microdeletions. One hundred seven of 765 (13.99%) non-obstructive azoospermic patients and 27 of 133 (20.30%) severe oligozoospermic patients had Y microdeletions. Among the 134 infertile men with Y microdeletions, the most frequent microdeletions were detected in the AZFc region, followed by AZFbc, AZFb, AZFa, AZFabc (Yq), Yp (SRY)+Yq, and partial AZFc regions. Karyotype analysis was available for 130 of the 134 patients with Y microdeletions. Of them, 36 (27.69%) patients had sex chromosomal abnormalities. Levels of FSH and LH in patients with AZFc microdeletion were significantly lower, while those in patients with Yp (SRY)+Yq were significantly higher than in patients without Y microdeletions. Level of testosterone in patients with AZFabc (Yq) or Yp (SRY)+Yq was significantly lower than that in patients without Y microdeletions. However, there was no significant difference in the levels of reproductive hormones between all patients with and without Y microdeletions.Conclusion: These results highlight the need for Y chromosome microdeletion screening for correct diagnosis of male infertility. Obtaining reliable genetic information for assisted reproductive techniques can prevent unnecessary treatment and vertical transmission of genetic defects to offspring.
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| Keyword(s): MALE INFERTILITY, NON-OBSTRUCTIVE AZOOSPERMIA, REPRODUCTIVE HORMONE, SEVERE OLIGOZOOSPERMIA, Y CHROMOSOME MICRODELETION |
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+ Click to Cite.
APA: CopyKIM, S., & KIM, H., & LEE, B., & PARK, S., & LEE, H., & SEO, J. (2017). Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA. JOURNAL OF REPRODUCTION AND INFERTILITY, 18(3), 307-315. https://www.sid.ir/en/journal/ViewPaper.aspx?id=568549 Vancouver: CopyKIM SHIN YOUNG, KIM HYUN JIN, LEE BOM YI, PARK SO YEON, LEE HYO SERK, SEO JU TAE. Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA. JOURNAL OF REPRODUCTION AND INFERTILITY. 2017 [cited 2022August14];18(3):307-315. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568549 IEEE: CopyKIM, S., KIM, H., LEE, B., PARK, S., LEE, H., SEO, J., 2017. Y CHROMOSOME MICRODELETIONS IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA AND SEVERE OLIGOZOOSPERMIA. JOURNAL OF REPRODUCTION AND INFERTILITY, [online] 18(3), pp.307-315. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=568549.
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