Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   3RD WEEK OCTOBER 2017 , Volume 35 , Number 443 #B0035; Page(s) 1038 To 1043.
 
Paper: 

CYCLOOXYGENASE-2 EXPRESSION IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

 
 
Author(s):  MOKHTARI MOZHGAN, HEDAYAT PEGAH*
 
* STUDENT RESEARCH COMMITTEE, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Cyclooxygenases-2 (COX) expression in cancer tissues is associated with worse prognosis of cancers. We studied cyclooxigenase-2 expression among patients with head and neck squamous cell carcinoma (HNSCC).
Methods: In a cross-sectional study performed in two university hospitals in Isfahan City, Iran, between the years 2011 and 2015, patients with newly pathological diagnosis of HNSCC were evaluated. Real-time polymerase chain reaction (real-time PCR) was used to evaluate the expression of cyclooxigenase-2 in surgical excised cancer tissues. Patients were followed-up for one year regarding recurrence and mortality. Association of cyclooxigenase-2 expression with clinicopathologic data and prognosis were analyzed.
Findings: Thirty cases of HNSCC with mean age of 59.6 years (70% men) were studied. Only 4 cases (13.3%) were cyclooxigenase-2 positive. Compared with cyclooxigenase-2 negative cases, those with cyclooxigenase-2 expression were relatively, but not significantly, older (71.0 ± 12.5 vs.57.8±12.0 years, P=0.054) and had larger tumor size (2.70 ± 1.19 vs.1.76 ± 0.84 cm, P=0.061), more frequent moderately/poorly differentiated tumors (50.0 vs.15.3 percent, P=0.190), and more frequent involvement of the lymph nodes (50.0 vs.7.6 percent, P=0.075). One of the cyclooxigenase-2 positive cases had metastasis. After one year follow-up, recurrence rate was 75.0% and 9.5% in cyclooxigenase-2 positive and negative cases, respectively (P=0.005).
Conclusion: We found that cyclooxigenase-2 expression in HNSCC patients is associated with worse clinicopathologic characteristics and prognosis. It may be used as a prognostic factor for HNSCC and also a target for treatment. Further studies with larger sample size are warranted in this regard.

 
Keyword(s): BIOLOGICAL MARKERS, CARCINOMA, SQUAMOUS CELL, HEAD AND NECK NEOPLASMS, CYCLOOXYGENASE
 
References: 
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