Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   EXPERIMENTAL ANIMAL BIOLOGY   SUMMER 2017 , Volume 6 , Number 1 (21) ; Page(s) 71 To 79.
 
Paper: 

MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT

 
 
Author(s):  BAGHSHANI HASAN*, GHODSI VAHIDE
 
* DEPARTMENT OF BASIC SCIENCES, SCHOOL OF VETERINARY MEDICINE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Abstract: 

Chronic cyanide intoxication hasbeen shown to induce damage in various tissues. In the present study the effects of chronic exposure to potassium cyanide (KCN) on some oxidative stress-related parameters as well as Modulatory effects of garlic powder were studied.18 male wistar rats were assigned into three groups, 6 in each group. Group 1 served as control group. Group 2 received cyanide (KCN, 500 mg/L) in drinking water for 42 days. Rats in Group 3 received water containing KCN (500 mg/L in drinking) and also were fed a diet containing 5% garlic powder for 42 days. Cyanide caused increase in malondialdehyde (MDA) concentartins in all studies tissues, although the increase was only significant (P<0.05) in kidney, heart and brain. Significant increase of protein carbonyls was also observed in liver and kidney following cyanide poisoning. Garlic supplementation in group 3 effectively decreased the augmented levels of MDA in kidney and brain to the levels that were not significantly different from control group. Moreover, values of protein carbonyl groups was also decreased notably in liver and kidney of group 3 to the levels that were not significantly different from control group. Results of the present study show that garlic has modulatory effect on cyanide-induced oxidative stress damage in rat and could have therapeutic and prophylactic effects on cyanide poisoning.

 
Keyword(s): CYANIDE POISONING, GARLIC, OXIDATIVE DAMAGE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 86
 
Latest on Blog
Enter SID Blog