Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2004 , Volume 9 , Number 1 (37); Page(s) 29 To 34.
 
Paper: 

ANTIMICROBIAL RESISTANCE OF STREPTOCOCCUS PNEUMONIAE ISOLATED FROM CSF AND SPUTUM IN PATIENTS WITH MENINGITIS AND PNEUMONIA

 
 
Author(s):  ZARGARIZADEH A., SHIRAZIAN J., ZAHRABI A.
 
* 
 
Abstract: 

Background: The rate of morbidity and mortality of pneumoncoccal infections especially bacteremia and meningitis is quite noticeable in case of remained untreated. The betalactam antibiotics are the drugs of choice to treat pneumococcal infections, however, recently emergence of beta lac tam resistant pneumococci, has necessitated more studies and development of proper strategies for treatment of such infections. In the present study, the susceptibility pattern of isolated pneumococci from hospitalized patients with meningitis and pneumonia was studied.
Materials and methods: It was a descriptive study. Having completed direct microscopic exam and culture, 50 strains of pneumococci from patients hospitalized in Pediatric Center, Loghman, Jam and Al-Qadir hospitals were isolated, then, susceptibility of isolates against penicillin, chloramphenicol, erythromycin, tetracycline, rifampin, vancomycin, ofloxacin, clindamycin, trimethoprim-sulfametoxazole, cefotaxime and ceftriaxone was determined by disk diffusion method and macro tube broth dilution method, based on the NCCLS recommendations.
Results: Totally, resistance of 50 isolates was as follows: trimethoprim-sulfamethoxazole 65%, penicillin 44%, erythromycin 26%, tetracycline 20%, chloramphenicol 16%, clindamycin 12%, cefotaxime 8%, ofloxacin 8%, ceftriaxone 6%, rifampin 2% and vancomycin 0%. In this study, pneumococcal strains showed no resistance against vancomycin. Strains have shown to be sensitive to vancomycin, rifampin, cefteriaxone, ofloxacin, and cefotaxime.
Conclusion: It is highly recommended to prescribe a combination of vancomycin and ceftriaxone or cefotaxime to treat penicillin-resistant strains (pneumococcal meningitis).

 
Keyword(s): STREPTOCOCCOUS PNEUMONIA, ANTIBIOTIC RESISTANCE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 60
 
Latest on Blog
Enter SID Blog