Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2004 , Volume 9 , Number 1 (37); Page(s) 1 To 6.
 
Paper: 

EFFECT OF FORMALIN TEST ON PERIPHERAL NEUROPATHY IN RAT

 
 
Author(s):  SEDAGHAT K., MANAHEJI H.
 
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Abstract: 

Abstract Background: Interphase is an important period of formalin test. Formalin has an effect on peripheral neuropathic pain. The present study was conducted to determine the effect of formalin test on peripheral neuropathy in rat.
Materials and methods: This experimental study was carried out on 40 male Sprague Dawley rats weighing 200 - 250 g. The rats divided in 5 groups randomly: group one (control) was injected by formalin once. Group two, sciatic ligation (Chronic Constriction Injury=CCI) was performed according to the Bennet & Xie method and on days 2 and 14 after CCI, formalin was injected. Group three, (Sham surgery) was injected by formalin on days 2 and 14 after surgery. Group four, had received formalin five days prior to CCI to the same paw and then on the days 2 and 14 after CCI formalin was injected again. Group five, 5 minutes prior to formalin injection, Lidocaine (iv 28mg/kg) was injected and then five days later, CCI was performed. Then, on days 2 and 14 after CCI formalin was injected again. In all experimental groups the interphase period of formalin test was considered.
Results: Results were as follows: On days 2 and 14 after CCI, group 2 has shown a significant difference with the control and Sham groups regarding the interphase period (p<0.05). Meanwhile, interphase period was revealed to be increased on day 14 as compared with the day 2 in groups 2 (p<0.01) and 5 (p<0.05). In group 4, the interphase of the second day was increased as compared to group 4 (p<0.01). Interphase of days 2 and 14 has shown no significant difference between groups 4 and 5, however, prior to CCI group 5 has shown a significantly lesser interphase (p<0.05).
Conclusion: It was revealed that pre neuropathic pain influences on post neuropathic pain, so it is highly recommended to alleviate the pre operative pain.

 
Keyword(s): FORMALIN TEST, INTERPHASE, CHRONIC CONSTRICTION INJURY
 
References: 
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