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Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   December 2004 , Volume 1 , Number 2; Page(s) 89 To 98.
 
Paper: 

COPPER/TOPAQUINONE-CONTAINING AMINE OXIDASE FROM LENTIL SEEDLINGS AND BOVINE PLASMA: CATALYTIC MECHANISM AND ENERGETIC DOMAINS

 
 
Author(s):  MEDDA R., LONGU S., AGOSTINELLI E., DALLA VEDOVA L., PEDERSEN J.Z., FLORIS G., MOUSAVI MOVAHEDI ALI AKBAR, PADIGLIA A.*
 
* University of Cagliari, Cagliari, Italy
 
Abstract: 
In this review the characteristics of the prosthetic group and the role of copper in amine oxidase purified from lentil seedlings are compared with the corresponding features of the amine oxidase isolated from bovine serum. Although both enzymes contain the same organic cofactor, the 6-hydroxydopa (2,4,5-trihydroxyphenethylamine) quinone, the catalytic cycle of lentil seedling amine oxidase operates through a Cu(I)-free-radical intermediate of the cofactor, whereas in bovine serum enzyme the radical form was not observed. The role of the metal in the catalytic mechanism of the two enzymes is also discussed. Moreover, the energetic domains and the effect of the temperature on activity, for both enzymes, are examined using differential scanning calorimetry.
 
Keyword(s): AMINE OXIDASE, COPPER, 6–HYDROXYDOPA, DIFFERENTIAL SCANNING CALORIMETRY, DECONVOLUTION
 
 
References: 
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Cite:
APA: Copy

MEDDA, R., & LONGU, S., & AGOSTINELLI, E., & DALLA VEDOVA, L., & PEDERSEN, J., & FLORIS, G., & MOUSAVI MOVAHEDI, A., & PADIGLIA, A. (2004). COPPER/TOPAQUINONE-CONTAINING AMINE OXIDASE FROM LENTIL SEEDLINGS AND BOVINE PLASMA: CATALYTIC MECHANISM AND ENERGETIC DOMAINS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 1(2), 89-98. https://www.sid.ir/en/journal/ViewPaper.aspx?id=5492



Vancouver: Copy

MEDDA R., LONGU S., AGOSTINELLI E., DALLA VEDOVA L., PEDERSEN J.Z., FLORIS G., MOUSAVI MOVAHEDI ALI AKBAR, PADIGLIA A.. COPPER/TOPAQUINONE-CONTAINING AMINE OXIDASE FROM LENTIL SEEDLINGS AND BOVINE PLASMA: CATALYTIC MECHANISM AND ENERGETIC DOMAINS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS). 2004 [cited 2021April14];1(2):89-98. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=5492



IEEE: Copy

MEDDA, R., LONGU, S., AGOSTINELLI, E., DALLA VEDOVA, L., PEDERSEN, J., FLORIS, G., MOUSAVI MOVAHEDI, A., PADIGLIA, A., 2004. COPPER/TOPAQUINONE-CONTAINING AMINE OXIDASE FROM LENTIL SEEDLINGS AND BOVINE PLASMA: CATALYTIC MECHANISM AND ENERGETIC DOMAINS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), [online] 1(2), pp.89-98. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=5492>.



 
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