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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003-2004 , Volume 8 , Number 5 (35); Page(s) 335 To 338.
 
Paper: 

PREVALENCE OF HUMAN PAPILLOMAVIRUS IN SQUAMOUS CELL CARCINOMA OF CERVIX IN PATIENTS REFERRING TO HOSPITALS AFFILIATED BY SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, 1999-2002

 
 
Author(s):  VESAL P., GHARIB G., AMINI SEDIGHEH
 
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Abstract: 

Background: Prior investigators have proposed the presence of human papillomavirus (HPV) in squamous cell of carcinoma. This may influence on prevention programs, epidemiologic studies, and of course, herapeutic approaches. The present study was conducted to estimate the prevalence of human papillomavirus in squamous cell carcinoma of cervix in patients referring to hospitals affiliated by Shaheed Beheshti University of Medical Sciences during a 3-year period (1999-2002).
Materials and methods: Forty patients ranging in age from 40 to 78 year were selected from registries of pathology departments, for whom, the diagnosis of cervical squamous cell carcinoma was confirmed. The histologic subtypes were identified and immunohistochemistry was performed. The prevalence of human papillomavirus was determined.
Results: A positive nuclear reaction was detected in 40% of cases (16 out of 40), 11 cases (69%) of which were in the large cell non-keratinizing group, 4 (25%) were in the large cell keratinizing group and 1 (6%) belonged to poorly differentiated small cell group. Statistical analyses showed no significant difference between the various groups.
Conclusion: Our findings indicated that the prevalence of HPV infection in squamous cell carcinoma of cervix in our country is lower than other countries. However, further investigations in larger scales, using more sensitive assays are necessary to estimate the true prevalence ofHPV infection in our country.

 
Keyword(s): HUMAN PAPILLOMAVIRUS, SQUAMOUS CELL CARCINOMA OF CERVIX
 
References: 
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