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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003-2004 , Volume 8 , Number 5 (35); Page(s) 321 To 326.
 
Paper: 

EFFECTS OF MACRONUTRIENTS ON METABOLIC RESPONSES IN NIDDM AND HEALTHY SUBJECTS

 
 
Author(s):  KASEB F., SOLTANI M., HOSEINI M., KIMIAGAR SEYED MASOUD
 
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Abstract: 

Background: Data regarding the effect of macronutrients on metabolic responses such as insulin, norepinephrine and blood sugar is not informative. This study was designed, therefore, to explore these effects.
Materials and methods: This clinical trial was carried out on 10 healthy subjects and 15 NIDDM (non-insulin-dependent diabetes mellitus) patients. Metabolic responses such as insulin, norepinephrine and blood sugar were determined before and 15, 30, 60, 90, 120 and 180 minutes after the intake of wheat starch, Na caseinat and olive oil. Statistical analyses were performed by analysis of variance with repeated measures, independent-t-test and dependent-t test.
Results: The study population included 10 healthy subjects (4 females and 6 males) with the mean age of 36.6±5.8 years, and mean BMI 24±1.2 Kg/m2; and 15 NIDDM subjects (4 females and 11 males) with the mean age of 38.9±5.2 years and mean BMI 24±1.6 Kg/m2. Metabolic responses in each group showed significant difference following the intake of macronutrients (p<0.05). Baseline insulin was higher in NIDDM patients (NS). Baseline norepinephrine was higher in healthy subjects (p<0.05). Insulin increased significantly following the intake of macronutrients in healthy subjects (p<0.05). The latter increased significantly following intake of carbohydrate and protein (p<0.05) however did not differ significantly following the fat intake. Norepinephrine increased significantly following the intake of carbohydrate, protein and fat in both groups (p<0.05). Postprandial blood sugar significantly increased in healthy subjects (p<0.05). However, in NIDDM subjects it increased significantly following the intake of carbohydrate and protein and diminished following the intake of fat (p<0.05). Postprandial systolic blood pressure increased in healthy subjects (p<0.05), while systolic blood pressure did not change significantly following intake of carbohydrate and protein. It was diminished after the intake of fat in NIDDM patients (p<0.05). Conclusion: The effects of macro nutrients on metabolic responses were different in healthy and NIDDM subjects. Further studies are highly recommended.

 
Keyword(s): MACRONUTRIENT, METABOLIC RESPONSE, NON-INSULIN-DEPENDENT DIABETES MELLITUS
 
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