Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003-2004 , Volume 8 , Number 5 (35); Page(s) 315 To 320.
 
Paper: 

PREVALENCE AND RISK FACTORS OF HEPATITIS C IN HEMODIALYSED PATIENTS

 
 
Author(s):  ALAVIAN M.*, EYN ELAHI BEHZAD, HAJARIZADEH B., BAKHTIARI S., NAFAR MOHSEN, AHRABI S.
 
* Dept. of Gastroenterology, Baghiatollah Medical Science University
 
Abstract: 

Backgrounds: Hepatitis C virus (HCV) infection is common among patients undergoing hemodialysis. Controlling HCV-related liver diseases is an important matter of health concern among such patients. Nowadays, liver diseases are a major cause of death in patients with end stage renal disease (ESRD). Materials and methods: To investigate the prevalence of HCV infection in patients on hemodialysis and its associated risk factors, we conducted a retrospective case series of 838 patients on hemodialysis in Tehran. Patients were selected randomly (cluster sampling) and all were checked for anti-HCV antibodies, using ELISA technique and then to confirm the positive samples with RlBA.
Results: Totally, 111 patients (13.2%) were infected. Considering univariate analysis, longer duration on hemodialysis (p=0.000), more weekly dialysis sessions (p=0.03), history of blood transfusion (p=0.03) and history of previous renal transplantation (p=0.01) were associated with higher rate of HCV infection. However, on multivariate analysis, hemodialysis duration (p=0.000) and blood transfusion (p=0.02) remain significant as risk factors for HCV acquisition. The more units transfused, the more the rate of HCV infection.
Conclusion: It seems that early transplantation and avoidance of blood transfusion as much as possible - for example by using erithropoietin- are the two most important practical interventions to reduce HCV exposure rate in patients on hemodialysis.

 
Keyword(s): BLOOD TRANSJUSION, HEPATITIS C, HEMODIALYSIS, KIDNEY FAILURE, RISKFACTORS
 
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