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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 2 (32); Page(s) 117 To 120.
 
Paper: 

DETERMINING THE ASSOCIATION BETWEEN KINSHIP AND PEMPHIGUS VULGARIS

 
 
Author(s):  NASIRI S.*, MINOO F., MALEKZAD F., GACHKAR L.
 
* Dept. of Dermatology, Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: Pemphigus vulgaris is a skin disease with mucocutaneous involvement. Although it is a rare disorder in some areas of the world, it's not considered to be so uncommon in Iran. Several etiologies have been proposed such as environmental factors, but there is no consensus on genetic factors. The present study was conducted in Loghman Hakim Hospital to determine the association between kinship and pemphigus vulgaris.
Materials and methods: For this case-control study, 100 subjects including a case group of 50 first relatives of patients with definite diagnosis of pemphigus vulgaris and 50 normal controls who had no previous history of bullous diseases even within their first relatives. Indirect immunofluorescence was used to measure antibodies against pemphigus vulgaris, meanwhile, clinical studies were achieved. T test and chi square were used for data analysis.
Results: The case group consisted of 18 males and 32 females with the mean age of 28.6± 17.4 years, and the control group included 19 males and 31 females with the mean age of 29.3±1.1. (NS). We could not detect any antibody against pemphigus vulgaris.
Conclusion: Negativity of antibody to pemphigus vulgaris in close relatives may be due to a technical shortage. Surveying this with other techniques such as immunoblotting, DIF, and HLA Typing on greater samples is highly recommended.

 
Keyword(s): PEMPHIGUS VULGARIS, KINSHIP
 
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