Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 2 (32); Page(s) 105 To 108.
 
Paper: 

STUDY THE RELATIONSHIP BETWEEN RADIOTHERAPY OF NONTHYROIDAL CANCERS OF HEAD AND NECK WITH THYROID DYSFUNCTION

 
 
Author(s):  ALIDOUSTI A.*, AKHAVAN A., AZARGASHB E.A.
 
* Dept. of Radiotherapy-Oncology, Shaheed beheshti University of Medical Sciences
 
Abstract: 

Background: With regard to thyroid dysfunction in patients treated by radiotherapy and this concern that radiotherapy of head and neck cancers employing Cobalt 60 machine that is still in use in our country might have adverse effects on thyroidal function of patients treated by radiotherapy the present study was performed in order to determine the relationship between radiotherapy of non-thyroidal cancers of head and neck and thyroid dysfunction in patients and the control group referring to radiotherapy clinic of Imam Hossein Hospital in 2001-2.
Material and methods: The study was performed using historical cohort on 60 patients consisting of 30 patients suffering from non-thyroidal cancers of head and neck as the case group and 30 patient with cancers except those of head and neck, brain and thyroid as control group. Patients were matched according to the age, sex and minimum radiation dose. Thyroid function was assessed according to a standard procedure using TSH and T4.
Results: The control group included 19 females and 11 males with the mean age (±SD) of 54.5±14.2 years and the case group included 12 females and 18 males with the mean age of 45.8±15.1 years (NS). TSH disorder was reported in 6.7% and 46.7% of the control and case group, respectively. Radiotherapy has increased the possibility of TSH disorder in nonthyroidal head and neck cancer 7 times. T4 disorder was revealed in 6.7% of the control and 13.3% of the case group.
Conclusion: Radiotherapy of non-thyroidal cancer of head and neck has led to disordered TSH.

 
Keyword(s): NONTHYROIDAL HEAD AND NECK CANCER, RADIOTHERAPY
 
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