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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 2 (32); Page(s) 79 To 86.
 
Paper: 

THE EFFECTS OF VITAMIN E SUPPLEMENT ON SERUM LIPIDS AND APOPROTEINS IN HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS

 
 
Author(s):  TABIBI H.*, SIASI F., JALALI A., MAHDAVI M., ESHRAGHIAN M.R.
 
* DEPARTMENT OF NEPHROLOGY , SHAHID BEHESHTI MEDICAL UNIVERSITY
 
Abstract: 

Background: Lipid abnormalities and oxidative stress are the two major risk factors for atherosclerosis in hemodialyzed patients. Therefore the present study was designed to determine the effects of vitamin E supplement on serum lipids and apoproteins in hypertriglyceridemic hemodialyzed patients.
Materials and methods: It was a double-blind randomized clinical trial. Twenty-six hemodialyzed patients from dialysis centers in Tehran with fasting triglyceride range of 230 to 500 mg/dl were randomly assigned to placebo or vitamin E (receiving 600 mg/d alpha-tocopherol acetate) groups. All patients received their supplements for 13 weeks. Venous blood (5ml) was drawn after a 12 to 14- hour fast at the beginning of the study and at the end of sixth and thirteenth weeks. Then, serum lipids and apoproteins were measured.
Results: During the study, two patients of the vitamin E group and one patient of placebo group were excluded. The results showed mean serum vitamin E concentration was significantly increased in vitamin E group compared to placebo group at the end of sixth and thirteenth weeks (P<0.01I). During 13 weeks, mean serum triglyceride was, reduced 62 mg/dl in vitamin E group but increased 84 mg/dl in placebo group (P<0.01). Also, mean serum total cholesterol, LDL-C/HDL-C ratio and apoB100 were significantly reduced in vitamin E group compared to placebo group (P< 0.05). There were no significant differences between mean serum HDL-C, LDL-C, apoAI and Lp(a) of the two groups.
Conclusion: Pharmacological doses of vitamin E have beneficial effects on serum lipids and apoproteins in hypertriglyceridemic hemodialyzed patients. It is suggested that future investigations be done with larger sample sizes and on various types of lipid abnormalities.

 
Keyword(s): VITAMIN E, HEMODIALYSIS, LIPIDS, APOPROTEINS
 
References: 
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