Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   Spring 2004 , Volume 9 , Number Part 1; Page(s) 21 To 28.
 
Paper: 

NATURAL KILLER CELLS ACTIVITY IN CANCER PATIENTS

 
 
Author(s):  ZANDYEH T.*, SHIKHYI A.K., ZAHIR M.H.
 
* 
 
Abstract: 
Objective. Natural killer (NK) cells are a subgroup of lymphocytes actively present in the spleen and circulation. These cells are the first line of defense against cancer, and have important roles in the immune system against cancer, for example leukemia, melanoma, breast cancer and others.
Materials and Methods. In these study evaluation of NKC activity in breast cancer, esophageal, rectum, melanoma, and stomach cancer patients compared with normal controls was assessed concurrently by chromium 51(Cr 51) release assay using the K562 cells as targets.
Results. Patients suffering from advanced esophageal, breast, rectum and other cancers exhibited significantly lower natural killer activity against K562 cells (%34.5) than did the normal group (69). (P Conclusion. These result suggest that the study of NKC activity may offer a key in Following the clinical course and the efficacy of cancer therapy.
 
Keyword(s): NATURAL KILLER CELL, CANCER, IMMUNE SYSTEM
 
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