Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   Summer 2004 , Volume 9 , Number Part 2; Page(s) 127 To 134.
 
Paper: 

EVALUATION OF THREE ANTI- H. PYLORI DRUG REGIMENS

 
 
Author(s):  AMINI MOHSEN*, KHEDMAT H.
 
* DEPT. OF GASTROENTEROLOGY, FACULTY OF MEDICINE, BAQIATALLAH(A.S) UNIVERSITY OF MEDICAL SCIENCES, TEHRAN
 
Abstract: 
Introduction. Finding a good antibiotic regimen to eradicate Helicobacter pylori (H. Pylori) depends on bacteriologic, epidemiologic and several background variables.
Materials and Methods. We conducted a randomized single - blind clinical trial, in which 245 dyspeptic patients (57% male; 43% female - aging 37.07 ± 11.83), attending to Baqiyatallah Hospital, were endoscopied and entered the study if their rapid urease test or culture were positive for Helicobacter pylori and randomly underwent therapy by one of A,B,C drug regimens as follow:
A: Omeprazole 20 mg I Bid, Bismuth subcitrate 120 mg II Bid, Metronidazole 250 mg II Bid and Tetracyline 250 mg II Bid.
B: Omeprazole 20 mg I Bid, Bismuth subcitrate 120 mg II Bid, Furazolidone 100 mg II Bid and Tetracyline 250 mg II Bid.
C: Omeprazole 20 mg I Bid, Bismuth subcitrate 120 mg II Bid and CiprofIoxacin 500 mg I Bid.
Then, for evaluating eradication of H.Pylori, C-14 urea breath test was done 1-2 months after the end of therapy.
Results. Out of 245 patients enrolled in the study, 228 completed a course of treatment, that successful eradication rate was 76.3%, 68.4% and 67.1 % in - groups A, B and C, respectively. There was no significant difference between groups, using chi-square test (CI=95%, a=0.05) classifying patients according to their sex, it was noted: The success rate of regimen C was significantly less than regimen B in female patients (P < 0.05). There was also good patient compliance to regimens.
Conclusion. The above drug regimens are less effective compared to others parts of the world.
 
Keyword(s): HELICOBACTER PYLORI, ERADICATION, DYSPEPS
 
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