Paper Information

Journal:   KOWSAR MEDICAL JOURNAL   Summer 2004 , Volume 9 , Number Part 2; Page(s) 101 To 110.
 
Paper: 

THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES

 
 
Author(s):  POURABOULI IRAN*, HAJIZADEH S., NAJAFIPOUR H., KHOUSHBATEN A.
 
* DEPT. OF PHYSIOLOGY, FACULTY OF MEDICINE, KERMAN UNIVERSITY OF MEDICAL SCIENCES,KERMAN,IRAN
 
Abstract: 
Objective . In this study the role of prostaglandins and adenosine receptors (A1/A2) on knee joint diameter and blood flow to saphenous nerve stimulation were investigated in chronically inflamed rats.
Materials and Methods . Inflammation was induced byintraarticular injection of 0.2 ml FCA and 3,7,14,21 days postinjection, knee joint diameter and blood flow changes to proximally cut saphenous nerve stimulation were assessed using micrometer and laser Doppler flowmeter, respectively. In inflamed groups receiving indomethacin (PGs inhibitor" 3mg/kg,i.p. daily) and theophylline (A1/A2-antagonist, 50mg/kg, i.p every 12 hours) these two variables were measured too.
Results. Knee joint diameter measurements enhances significantly during inflammatIon (at 3-14 days) and theophylline (50 mg/kg,i.p, A1/A2- antagonist) decreased it on day 14th (18.1±3.6 v.s 7.9±1.9) but indomethacin (3 mg/kg,i.p, daily) was ineffective on it during 3 weeks. The response of articular microvasculature to nerve stimulation in normal and inflamed joints show that the constricting response to nerve stimulation was reduced significantly in inflamed group at 7,14 days especially on day 14th (-57.3±6.7 v.s -6.7±6.5) and indomethacin (3 mg /kg, i.p) enhanced constricting response 3,14 days after inflammation induction, however theophylline (50 mg/kg,i.p) reduced constricting response to nerve stimulation at 3,7 days.
Conclusion . Therefore chronic inflammation has reduced constricting response of knee joint blood vessels to saphenous nerve stimulation and prostaglandins and adenosine receptors play a role in this modulation.
 
Keyword(s): INDOMETHACIN, THEOPHYLLINE CHRONIC INFLAMMATION, BLOOD FLOW, KNEE JOINT
 
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