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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   Winter 2004 , Volume 5 , Number Supplement (4); Page(s) 355 To 361.
 
Paper: 

ASSOCIATION BETWEEN THE CHOLESTERYL ESTER TRANSFER PROTEIN_TAQI POLYMORPHISM AND LOW HDL-C CONCENTRATION TEHRAN POPULATION

 
 
Author(s):  DANESHPOUR M.A.S., HEDAYATI S.M., AZIZI F., AZARI F., GHASEMI F.
 
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Abstract: 

Introduction: There is an association between the common CETP polymorphism, Taql in intron 1, with HDL level in some populations. We studied this association because of low levels of high density lipoprotein in Iranian population.
Materials and Methods: To examine the relation between Taql polymorphism and high density lipoprotein level, 1021 people from TLGS in Tehran (467 men and 554 women) were selected. We measured HDL-C, triglycerides and cholesterol level and accounted for factors that are known to influence HDL cholesterol level, such as smoking, body mass index and blood pressure. We amplified a segment of mentioned gene with PCR and then revealed the polymorphism with RFLP.
Result: The B2 (cutting site absent) allele frequency was 0.378 in men and O. 386 in women, and its presence, was significantly associated with increased levels of HDL-C (8181, 1.0±0.2 mmol/L; 8282, 1.19±0.31 mmol/L; P<0.001) in the whole population, but no significant relationship was observed in men. This genetic variation was independent of metabolic risk factors known to influence HDL levels.
Conclusion: These data demonstrate that variation at the CETP gene locus is a significant determinant of HDL-C level in this population

 
Keyword(s): CHOESTERYL ESTER TRANSFER PROTEIN, HDL-C, POLYMORPHISM, TAQI
 
References: 
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