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Paper Information

Journal:   IRANIAN JOURNAL OF BIOLOGY   Spring-Summer 2003 , Volume 14 , Number 1-2; Page(s) 12 To 21.
 
Paper: 

EFFECT OF LEAD NITRATE OR ALVEOLAR MACROPHAGES

 
 
Author(s):  SHABANI ASHRAF, RABBANI GHADGHANI A.
 
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Abstract: 
Macrophages are one of the most important cells in the immune system that plays important role in immunoregulatory against poisoning and different infections. Lead is one of the heavy metals that it's poisoning is responsible for a variety of pathological states. In this study we have attempted to characterize the effect of various concentrations of lead nitrate on alveolar macrophages. After incubation for different period and different concentrations of lead nitrate. The survival rate. Anion super oxide production. DNA fragmentation and cytological analysis Vivre determined. The results show that after 3 and 6 hours of exposure of alveolar macrophages to low concentrations of lead nitrate (15-60uM) the survival rate is above 87% and in high concentrations of lead nitrate the survival rate is less than 80% DNA fragmentation was analyzed by diphenylamine reaction. After, and 6 hours of exposure significant increase in DNA fragmentation and anion superoxide production was observed. Cytological anal. Sis revealed that at low, concentrations of lead nitrate and short period of time. The nucleolus of the cells was condensed and fragmented. Whereas at high concentrations of lead nitrate and long period of times. It was swollen and the integrity of the membrane was lost. It is suggested that at low concentrations of lead nitrate. The cells go under apoptosis. At high concentrations causes necrosis.
 
Keyword(s): LEAD, MACROPHAGE, APOPTOSIS, NECROSIS
 
References: 
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