Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   WINTER 2004 , Volume 5 , Number 4 (SN 20); Page(s) 227 To 236.
 
Paper: 

EFFECT OF A2-ADRENERGIC ANTAGONIST ON SOME FACTORS SECRETED ADIPOSE TISSUE IN OBESE MALE RATS

 
 
Author(s):  ESFANDI F., PAJHAN N., MOHAMMAD TAGHVAEI N., KOMEYLI MOVAHED T.
 
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Abstract: 
Introduction: Obesity is a major risk factor for type 2 diabetes, hypertension, hyperlipidemia, cardiovascular disease and certain types of cancer. Furthermore, obesity is associated with insulin resistance and hyperinsulinaemia. Hormones and cytokines such as leptin and TNF-a. are produced by adipose tissue and have a key role in insulin resistance of obesity. The purpose of this study was to examine the effects of peripheral administration of yohimbine on some of adipose factors.
Materials and Methods: Experiments were carried out on two groups of male rats: lean control group (fed standard purina rodent chow) and obese group (fed cafeteria diet). A blood sample was taken from each rat, after exposure to diet for 18 weeks. The obese group were randomly divided into two groups. Group I was injected with 4mg/kg yohimbine and group II received the equal volume of saline. Blood samples were taken 30, 60, and 120 min after drug or saline injection.
Results: Insulin level was significantly increased 30 and 60 minutes after injection (P<0.05). TNF-a and leptin levels were decreased (P<0.05) while FFA level was increased in response to yohimbine, 30 minutes after injection. Glucose level was increased but it was lower than control group during 120 minutes.
Conclusion: It has been shown previously that cAMP is the main regulatory factor of leptin, TNF-a and FFA in adipocytes. In comparison to the obtained results in the control group, we conclude that probably sensitivity of a2- adrenergic receptors and a2/b-AR proportion are increased in obesity.
 
Keyword(s): OBESITY,A2- ADRENERGIC RECEPTOR, YOHIMBINE, CAMP, LEPTIN, TNF-A, FFA
 
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