Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   Summer 2003 , Volume 5 , Number 2 (SN 18); Page(s) 83 To 87.
 
Paper: 

SERUM RETINOL CONCENTRATIONS IN CHILDREN WITH TYPE 1 DIABETES: RELATIONSHIP WITH METABOLIC CONTROL INDICES

 
 
Author(s):  RAZAGHI AZAR MARYAM, RASHIDI A., FALAHAT PISHEH H.R., GARG M., MOHAMMADPOUR B., GHARAVI NOURI A., MOHAMMAD K., KIMIAGAR SEYED MASOUD
 
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Abstract: 

Introduction: Decreased serum retinol concentrations accompanied with increased hepatic retinyl ester levels have been shown in patients with type 1 diabetes mellitus (T1DM). It seems, therefore, that metabolic availability of vitamin A is impaired in T1DM. Since exogenous insulin acts as a key releasing factor for hepatic stores of vitamin A, it can be assumed that insulin insufficiency will affect both serum retinol and metabolic control indices at the same time. This study was designed to determine serum retinol level, its importance and correlation with routine metabolic control indices in a group of children with T1DM.

Material and Methods: Fasting blood samples were drawn from 24 children (6-14 years old) with at least 1.5 years history of T1DM. Patients who were chosen, did not have any other systemic disease, thyroid disorder, or chronic complications of diabetes, like nephropathy, retinopathy, neuropathy, etc. Serum retinol, FBS, HbA1c, total cholesterol (TC), HDL-C and triglyceride levels were measured. LDL-C was calculated. Calculation of Pearson correlation coefficients and regression analysis were done by Excel software.

Results: Mean ± SD of serum retinol level was 0.375 ± 0.068 μg/ml (1.313 ± 0.238 μM). Pearson correlation coefficients between fasting serum retinol and FBS, HbA1c, TC, HDL-C, LDL-C and TG levels were - 0.27, -0.08, 0.60, 0.21, 0.29 and 0.02, respectively. None, except TC (P<0.002), was significant.

Conclusion: Serum retinol levels in children with T1DM were within lower limits of normal range. There was a linear correlation between serum retinol and TC levels. Therefore, it seems that routine metabolic control indices, except TC, cannot be used to predict serum vitamin A status in patients with T1DM

 
Keyword(s): SERUM RETINOL, TYPE I DIABETES, METABOLIC CONTROL
 
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