Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   October 2004 , Volume 8 , Number 4; Page(s) 179 To 183.
 
Paper: 

TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE

 
 
Author(s):  ALIZADEH Z.*, PASBAKHSH P., SOBHANI A., BARBARESTANI M., GHAFARI M., ETESAM F.
 
* 
 
Abstract: 
Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this study, using real-time RT-PCR method, we defined the time course of degradation and deadenylation of an oocyte specific gene (c-mos) more precisely and a gene that is re-synthesized after ZGA (cyclin A2). Our data indicate that oocyte-specific transcript, c-mos, degrades rapidly while cyclin A2 mRNA does not and the deadenylation of c-mos mRNA precedes the process of degradation. Our findings suggest that time-dependent elimination of different maternal mRNA is a way for regulation of translation in early development of mouse embryos.
 
Keyword(s): MATERNAL MRNA, MOUSE EMBRYO, MRNA DEGRADATION, C-MOS, CYCLIN A2
 
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