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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   October 2004 , Volume 8 , Number 4; Page(s) 179 To 183.
 
Paper: 

TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE

 
 
Author(s):  ALIZADEH Z.*, PASBAKHSH P., SOBHANI A., BARBARESTANI M., GHAFARI M., ETESAM F.
 
* 
 
Abstract: 
Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this study, using real-time RT-PCR method, we defined the time course of degradation and deadenylation of an oocyte specific gene (c-mos) more precisely and a gene that is re-synthesized after ZGA (cyclin A2). Our data indicate that oocyte-specific transcript, c-mos, degrades rapidly while cyclin A2 mRNA does not and the deadenylation of c-mos mRNA precedes the process of degradation. Our findings suggest that time-dependent elimination of different maternal mRNA is a way for regulation of translation in early development of mouse embryos.
 
Keyword(s): MATERNAL MRNA, MOUSE EMBRYO, MRNA DEGRADATION, C-MOS, CYCLIN A2
 
 
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APA: Copy

ALIZADEH, Z., & PASBAKHSH, P., & SOBHANI, A., & BARBARESTANI, M., & GHAFARI, M., & ETESAM, F. (2004). TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE. IRANIAN BIOMEDICAL JOURNAL, 8(4), 179-183. https://www.sid.ir/en/journal/ViewPaper.aspx?id=5221



Vancouver: Copy

ALIZADEH Z., PASBAKHSH P., SOBHANI A., BARBARESTANI M., GHAFARI M., ETESAM F.. TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE. IRANIAN BIOMEDICAL JOURNAL. 2004 [cited 2021May15];8(4):179-183. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=5221



IEEE: Copy

ALIZADEH, Z., PASBAKHSH, P., SOBHANI, A., BARBARESTANI, M., GHAFARI, M., ETESAM, F., 2004. TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE. IRANIAN BIOMEDICAL JOURNAL, [online] 8(4), pp.179-183. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=5221.



 
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