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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   SUMMER 2013 , Volume 1 , Number 3; Page(s) 23 To 26.
 
Paper: 

THE EFFECT OF CORTICAL SPREADING DEPRESSION ON GLUTAMATE RECEPTORS IN RAT BRAIN

 
DOI: 

10.18869/acadpub.shefa.1.3.23

 
Author(s):  ALIPOUR FATEMEH, MOHAMMADZADEH ELHAM, KARIMZADEH FARIBA*
 
* SHEFA NEUROSCIENCE RESEARCH CENTER, TEHRAN, IRAN
 
Abstract: 

Introduction: Spreading depression (SD) is an intrinsic bioelectrical activity in central nervous system which play important role in pathophysiology of some disorders such as migraine with aura, epilepsy, transient global amnesia, and spinal cord diseases.
Materials and Methods: The juvenile rats were anesthetized and recording electrodes and cannula were implanted over the brain. Repetitive cortical SD events were induced by KCl injection through the cannula. Four weeks after the KCl or Ringer injection, all rats, including control, sham and SD groups, were decapitated and the brains removed. The distribution of NR2B subunit of NMDA receptors and the GluR1 subunit of AMPA receptors were assessed by immunohistochemical staining.
Results: Expression of NR2B receptors in the CA1 region significantly increased in the SD group compared with the sham and control group (P<0.05). Also expression of GluR1 receptors in the CA1 and CA3 regions significantly increased in the SD group (P<0.01).
Conclusion: Our result showed that SD enhanced expression of the NR2B subunit of NMDA receptors and the GluR1 subunit of AMPA receptors in various regions of the juvenile rat brain.

 
Keyword(s): BRAIN, GLUTAMATES, MIGRAINE DISORDERS, EPILEPSY
 
References: 
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