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Paper Information

Journal:   TRAUMA MONTHLY   FEBRUARY 2016 , Volume 21 , Number 1; Page(s) 0 To 0.
 
Paper: 

EFFICACY OF INTRAVENOUS PARACETAMOL VERSUS INTRAVENOUS MORPHINE IN ACUTE LIMB TRAUMA

 
 
Author(s):  JALILI MOHAMMAD*, MOZAFFARPOUR NOORI ALI, SEDAGHAT MOJTABA, SAFAIE ARASH
 
* DEPARTMENT OF EMERGENCY MEDICINE, IMAM HOSPITAL, KESHAVARZ BOULEVARD, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Background: Efficient pain management is one of the most important components of care in the field of emergency medicine.
Objectives: This study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma.
Patients and Methods: In a randomized double-blinded clinical trial, all patients (aged 18 years and older) with acute limb trauma and a pain score of greater than 3/10 in the emergency department were recruited; they received either 1 g intravenous paracetamol or 0.1 mg/kg intravenous morphine sulfate over 15 minutes. The primary outcome was the pain score measured on a numerical rating scale at 0, 15 and 30 minutes after commencing drug administration. The requirement for rescue analgesia and the frequency of adverse reactions were also recorded.
Results: Sixty patients randomly received either IV paracetamol (n = 30) or IV morphine (n = 30). The mean reduction in numerical rating scale pain intensity scores at 30 minutes was 3.86 (± 1.61) for paracetamol, and 2.16 (± 1.39) for morphine. However, pain relief was significantly higher in the paracetamol group compared to the morphine group (P < 0.001). Four patients in the paracetamol group and 15 patients in the morphine group needed rescue analgesia and the difference was significant (P = 0.05).
Conclusions: Intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. Further larger studies are required.

 
Keyword(s): ANALGESICS, ACUTE PAIN, ACETAMINOPHEN, MORPHINE, ACETAMINOPHEN
 
 
References: 
 
Citations: 
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APA: Copy

JALILI, M., & MOZAFFARPOUR NOORI, A., & SEDAGHAT, M., & SAFAIE, A. (2016). EFFICACY OF INTRAVENOUS PARACETAMOL VERSUS INTRAVENOUS MORPHINE IN ACUTE LIMB TRAUMA. TRAUMA MONTHLY, 21(1), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511754



Vancouver: Copy

JALILI MOHAMMAD, MOZAFFARPOUR NOORI ALI, SEDAGHAT MOJTABA, SAFAIE ARASH. EFFICACY OF INTRAVENOUS PARACETAMOL VERSUS INTRAVENOUS MORPHINE IN ACUTE LIMB TRAUMA. TRAUMA MONTHLY. 2016 [cited 2021July24];21(1):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511754



IEEE: Copy

JALILI, M., MOZAFFARPOUR NOORI, A., SEDAGHAT, M., SAFAIE, A., 2016. EFFICACY OF INTRAVENOUS PARACETAMOL VERSUS INTRAVENOUS MORPHINE IN ACUTE LIMB TRAUMA. TRAUMA MONTHLY, [online] 21(1), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511754.



 
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