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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   2016 , Volume 20 , Number 4; Page(s) 241 To 245.
 
Paper: 

BIRC5 GENOMIC COPY NUMBER VARIATION IN EARLY-ONSET BREAST CANCER

 
DOI: 

10.7508/ibj.2016.04.009

 
Author(s):  GHAFFARI KIMIA, HASHEMI MEHRDAD, EBRAHIMI ELMIRA, SHIRKOOHI REZA*
 
* GROUP OF GENETICS, CANCER MODELS RESEARCH CENTER, CANCER INSTITUTE OF IRAN, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tissues of breast cancer were obtained from Tumor Bank of Cancer Institute, Imam Khomeini Hospital, Tehran, Iran. BIRC5 gene copy number variation (CNV) was evaluated using Multiplex Ligation-dependent Probe Amplification (MLPA) and then compared with the age of onset for each patient. Results: BIRC5 amplification was seen in 17.5% of cases. Also, a significant association was observed between BIRC5 gene amplification and individuals under 40 years of age (P=0.04). Conclusion: BIRC5 gene has the potential to be a marker for the detection and prognosis of cancer at an early age.

 
Keyword(s): BIRC5, MLPA, BREAST CANCER, AMPLIFICATION
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

GHAFFARI, K., & HASHEMI, M., & EBRAHIMI, E., & SHIRKOOHI, R. (2016). BIRC5 GENOMIC COPY NUMBER VARIATION IN EARLY-ONSET BREAST CANCER. IRANIAN BIOMEDICAL JOURNAL, 20(4), 241-245. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511720



Vancouver: Copy

GHAFFARI KIMIA, HASHEMI MEHRDAD, EBRAHIMI ELMIRA, SHIRKOOHI REZA. BIRC5 GENOMIC COPY NUMBER VARIATION IN EARLY-ONSET BREAST CANCER. IRANIAN BIOMEDICAL JOURNAL. 2016 [cited 2021August04];20(4):241-245. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511720



IEEE: Copy

GHAFFARI, K., HASHEMI, M., EBRAHIMI, E., SHIRKOOHI, R., 2016. BIRC5 GENOMIC COPY NUMBER VARIATION IN EARLY-ONSET BREAST CANCER. IRANIAN BIOMEDICAL JOURNAL, [online] 20(4), pp.241-245. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511720.



 
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