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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   2016 , Volume 20 , Number 4; Page(s) 1 To 6.
 
Paper: 

ACTIVATION OF TOLL-LIKE RECEPTORS 2 BY HIGH-MOBILITY GROUP BOX 1 IN MONOCYTES FROM PATIENTS WITH ISCHEMIC STROKE

 
DOI: 

10.7508/ibj.2016.04.006

 
Author(s):  SADAT HATAMNEZHAD LEILA, TANOMAND ASGHAR, MAHMOUDI JAVAD, SANDOGHCHIAN SHOTORBANI SIAMAK*
 
* DEPT. OF IMMUNOLOGY, TABRIZ BRANCH, ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

Background: Stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. Toll-like receptors (TLRs) are important molecules for detection of both pathogen invasion and tissue damage. In this regard, the purpose of this study was to assess the expression level of TLR2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 (HMGB1) stimulation. Methods: A total of 30 patients with ischemic stroke were enrolled from November 2013 to September 2014. The real-time PCR and ELISA assays were applied to detect the concentrations of TLR2 mRNAs. Results: TLR2 expression was found to be increased in patients with ischemic stroke, as compared to the healthy control group (P<0.001). Also, anti-TLR2 antibodies were able to decrease the expression levels of IL-17, IL-6 and IL-33. This result implies that the enhanced TLR2 pathway and Th17 cell polarization may be due to HMGB1 stimulation in ischemic stroke. Conclusion: Further clinical studies are needed for development of a new treatment strategy to inhibit the HMGB1 pathway, thus preventing the inflammation in ischemic stroke patients.

 
Keyword(s): TOLL-LIKE RECEPTOR 2, HIGH-MOBILITY GROUP BOX 1, STROKE
 
 
References: 
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Citations: 
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APA: Copy

SADAT HATAMNEZHAD, L., & TANOMAND, A., & MAHMOUDI, J., & SANDOGHCHIAN SHOTORBANI, S. (2016). ACTIVATION OF TOLL-LIKE RECEPTORS 2 BY HIGH-MOBILITY GROUP BOX 1 IN MONOCYTES FROM PATIENTS WITH ISCHEMIC STROKE. IRANIAN BIOMEDICAL JOURNAL, 20(4), 1-6. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511708



Vancouver: Copy

SADAT HATAMNEZHAD LEILA, TANOMAND ASGHAR, MAHMOUDI JAVAD, SANDOGHCHIAN SHOTORBANI SIAMAK. ACTIVATION OF TOLL-LIKE RECEPTORS 2 BY HIGH-MOBILITY GROUP BOX 1 IN MONOCYTES FROM PATIENTS WITH ISCHEMIC STROKE. IRANIAN BIOMEDICAL JOURNAL. 2016 [cited 2021July30];20(4):1-6. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511708



IEEE: Copy

SADAT HATAMNEZHAD, L., TANOMAND, A., MAHMOUDI, J., SANDOGHCHIAN SHOTORBANI, S., 2016. ACTIVATION OF TOLL-LIKE RECEPTORS 2 BY HIGH-MOBILITY GROUP BOX 1 IN MONOCYTES FROM PATIENTS WITH ISCHEMIC STROKE. IRANIAN BIOMEDICAL JOURNAL, [online] 20(4), pp.1-6. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511708.



 
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