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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   2016 , Volume 20 , Number 4; Page(s) 187 To 188.
 
Paper: 

SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IN THE ADIPONECTIN GENE AND CARDIOVASCULAR DISEASE (LETTER TO THE EDITOR)

 
 
Author(s):  CHIRUMBOLO SALVATORE*
 
* DEPARTMENT OF MEDICINE-UNIT OF GERIATRY, LURM EST POLICLINICO GB ROSSI, PIAZZALE AL SCURO 10, 37134 VERONA, ITALY
 
Abstract: 

Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorphism in the Q gene of adiponectin has been reported for 3’-UTR, which harbours some genetic loci associated with metabolic risks and atherosclerosis[4]. Actually, previous studies have shown that the haplotype SNP +276G>T was associated with a decreased risk of CAD, after adjustment for potential confounding factors, therefore some controversial opinion still exists[5]. This evidence should be associated with the role exerted by adipocytes and adiponectin in heart physiology. In particular, in hypertensive disorder complicating pregnancy (HDCP), by investigating the population frequency of alleles, genotypes, and haplotypes of two single nucleotide polymorphisms (SNPs), namely +45T>G (rs2241766) and +276G>T (rs1501299), some authors found that the SNP +276 TT genotype was significantly associated with protection against HDCP, when compared to the pooled G genotypes[6].

 
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APA: Copy

CHIRUMBOLO, S. (2016). SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IN THE ADIPONECTIN GENE AND CARDIOVASCULAR DISEASE (LETTER TO THE EDITOR). IRANIAN BIOMEDICAL JOURNAL, 20(4), 187-188. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511685



Vancouver: Copy

CHIRUMBOLO SALVATORE. SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IN THE ADIPONECTIN GENE AND CARDIOVASCULAR DISEASE (LETTER TO THE EDITOR). IRANIAN BIOMEDICAL JOURNAL. 2016 [cited 2021July26];20(4):187-188. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511685



IEEE: Copy

CHIRUMBOLO, S., 2016. SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IN THE ADIPONECTIN GENE AND CARDIOVASCULAR DISEASE (LETTER TO THE EDITOR). IRANIAN BIOMEDICAL JOURNAL, [online] 20(4), pp.187-188. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511685.



 
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