Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2016 , Volume 6 , Number 2; Page(s) 235 To 245.
 
Paper: 

EVALUATING SUPEROXIDE DISMUTASE (SOD), GLUTATHIONE (GSH), MALONDIALDEHYDE (MDA) AND THE HISTOLOGICAL CHANGES OF THE LUNG TISSUE AFTER G-IRRADIATION IN RATS

 
 
Author(s):  REZAEYAN A., HADDADI GH.*, HOSSEINZADEH M.
 
* DEPARTMENT OF MEDICAL PHYSICS, SCHOOL OF MEDICINE, FASA UNIVERSITY OF MEDICAL SCIENCES, FASA, IRAN
 
Abstract: 

Background & Objective: The lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. Different side effects such as pneumonia and lung fibrosis are found in patients with thorax irradiation. The objective of the present study is to evaluate the effects of g-irradiation on acute and chronic injuries of lung tissue in rats.
Materials & Methods: 32 rats were divided into two groups. Control group consisted of 14 rats that underwent shame irradiation. In radiation group, 18 rats underwent
g-irradiation. The rats were exposed to g-irradiation 18 Gy using a single fraction cobalt-60 unit. Eight rats in each group were sacrificed 24 hours after radiotherapy for determining Superoxide Dismutase (SOD), Glutathione (GSH), Malondialdehyde (MDA), and histopathological evaluations. Remained animals were sacrificed eight weeks after radiotherapy for histopathological evaluation.
Results: Compared to control group, the level of SOD and GSH significantly decreased and MDA level significantly increased in radiation group 24 hours following irradiation, (p=0.001, p<0.001, p=0.001) respectively. Early histopathological results after 24 hours showed that radiation increases neutrophil, macrophage, and inflammation incidence compared to control group (p<0.05). Late histopathological evaluation after eight weeks revealed significant increase in factors including mast cells, pulmonary edema, vascular thickness, vascular damage, and also inflammation and fibrosis incidence in case group compared to radiation group (p<0.05).
Conclusion: Localized chest radiation with dose of 18 Gy induces changes in oxidative stress indices and histopathological lung tissue damage in short and long term.

 
Keyword(s): SUPEROXIDE DISMUTASE, GLUTATHIONE, MALONDIALDEHYDE, HISTOPATHOLOGY, GAMMA-RADIATION
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

REZAEYAN, A., & HADDADI, G., & HOSSEINZADEH, M. (2016). EVALUATING SUPEROXIDE DISMUTASE (SOD), GLUTATHIONE (GSH), MALONDIALDEHYDE (MDA) AND THE HISTOLOGICAL CHANGES OF THE LUNG TISSUE AFTER G-IRRADIATION IN RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, 6(2), 235-245. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511678



Vancouver: Copy

REZAEYAN A., HADDADI GH., HOSSEINZADEH M.. EVALUATING SUPEROXIDE DISMUTASE (SOD), GLUTATHIONE (GSH), MALONDIALDEHYDE (MDA) AND THE HISTOLOGICAL CHANGES OF THE LUNG TISSUE AFTER G-IRRADIATION IN RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021August03];6(2):235-245. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511678



IEEE: Copy

REZAEYAN, A., HADDADI, G., HOSSEINZADEH, M., 2016. EVALUATING SUPEROXIDE DISMUTASE (SOD), GLUTATHIONE (GSH), MALONDIALDEHYDE (MDA) AND THE HISTOLOGICAL CHANGES OF THE LUNG TISSUE AFTER G-IRRADIATION IN RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, [online] 6(2), pp.235-245. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511678.



 
 
Persian Abstract Yearly Visit 38
 
 
Latest on Blog
Enter SID Blog