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Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2016 , Volume 6 , Number 2; Page(s) 188 To 193.
 
Paper: 

THE ROLE OF RS2227956 HSPA1L GENE POLYMORPHISM IN IDIOPATHIC MALE INFERTILITY

 
 
Author(s):  KOHAN L.*, TABIEE O.
 
* DEPARTMENT OF BIOLOGY, ARSANJAN BRANCH, ISLAMIC AZAD UNIVERSITY, ARSANJAN, IRAN
 
Abstract: 

Background & Objective: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Despite the methodological advancements, the possible causes of infertility are still unknown for more than 25 percent of cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1L rs2227956 gene polymorphism in the idiopathic infertility in males.
Material & Methods: This case control study was conducted on 342 subjects consisted of 143 patients with idiopathic male infertility and 199 control subjects. Followed by the DNA extraction from the peripheral blood, genotype determination was done by PCR-restriction fragment length polymorphism method. The logistic regression analysis was used to estimate the association between the polymorphism and male infertility.
Results: A significant difference was observed in the genotype distributions between the cases and controls. The results showed that the individuals with TC and CC genotype had an increased risk of male infertility. In addition, there was a significant association between C allele and male infertility.
Conclusion: HSPA1L rs2227956 polymorphism is associated with the idiopathic male infertility risk.

 
Keyword(s): MALE INFERTILITY, IDIOPATHIC, POLYMORPHISM, HSP
 
 
References: 
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Citations: 
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APA: Copy

KOHAN, L., & TABIEE, O. (2016). THE ROLE OF RS2227956 HSPA1L GENE POLYMORPHISM IN IDIOPATHIC MALE INFERTILITY. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, 6(2), 188-193. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511658



Vancouver: Copy

KOHAN L., TABIEE O.. THE ROLE OF RS2227956 HSPA1L GENE POLYMORPHISM IN IDIOPATHIC MALE INFERTILITY. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021July30];6(2):188-193. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511658



IEEE: Copy

KOHAN, L., TABIEE, O., 2016. THE ROLE OF RS2227956 HSPA1L GENE POLYMORPHISM IN IDIOPATHIC MALE INFERTILITY. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, [online] 6(2), pp.188-193. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511658.



 
 
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