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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   JULY 2016 , Volume 20 , Number 3; Page(s) 152 To 160.
 
Paper: 

ASSOCIATION OF TWO COMMON SINGLE NUCLEOTIDE POLYMORPHISMS (+45T/G AND +276G/T) OF ADIPOQ GENE WITH CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS

 
DOI: 

10.7508/ibj.2016.03.004

 
Author(s):  MOHAMMADZADEH GHORBAN*, GHAFFARI MOHAMMAD ALI, HEIBAR HABIB, BAZYAR MOHAMMAD
 
* HYPERLIPIDEMIA RESEARCH CENTER, DEPARTMENT OF CLINICAL BIOCHEMISTRY, FACULTY OF MEDICINE, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Background: Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of ADIOPQ gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM).
Methods: Genotypes of two SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in 200 subjects with T2DM (100 subjects with CAD and 100 without CAD).
Results: The frequency of TT genotype of +276G/T was significantly elevated in CAD compared to controls (?2=7.967, P=0.019). A similar difference was found in the allele frequency of +276G/T between two groups (?2=3.895, P=0.048). The increased risk of CAD was associated with +276 TT genotype when compared to reference GG genotype (OR=5.158; 95% CI=1.016-26.182, P=0.048). However, no similar difference was found in genotype and allele frequencies of SNP +45T/G between two groups. There was a CAD protective haplotype combination of +276 wild-type and +45 mutant-type allele (276G-45G) (OR=0.37, 95% CI=0.16-0.86, P=0.022) in the subject population.
Conclusion: Our findings indicated that T allele of SNP +276G/T is more associated with the increased risk of CAD in subjects with T2DM. Also, a haplotype combination of +45G/+276G of these two SNPs has a protective effect on the risk of CAD.

 
Keyword(s): ADIPONECTIN, TYPE 2 DIABETES, CRONARY ARTERY DISEASE, SINGLE NUCLEOTIDE POLYMORPHISMS
 
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