Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2016 , Volume 6 , Number 2; Page(s) 155 To 161.
 
Paper: 

THE EFFECT OF TRIBULUS TERRESTRIS EXTRACT ON HEPATIC COMPLICATIONS DUE TO THE GELOFEN CONSUMPTION IN ADULT FEMALE RATS

 
 
Author(s):  HEJAZI L., HOSSEINI S.E.*
 
* DEPARTMENT OF BIOLOGY, SHIRAZ BRANCH, ISLAMIC AZAD UNIVERSITY, SHIRAZ, IRAN
 
Abstract: 

Background & Objective: Gelofen is one of the anti-inflammatory drugs which is used to relieve the pain and reduce the inflammations. This drug has side effects on body's tissues. This study aimed to investigate the effect of Tribulus terrestris (Tt) plant on hepatic transaminases due to the Gelofen consumption.
Materials & Methods: In this experimental study 56 rats were divided into 7 groups of 8 rats, including control, sham and 4 experimental groups receiving Gelofen 400mg / kg, Tt extract 80 mg / kg, Tt extract 20mg / kg and Gelofen with 400mg / kg doses, Tt extract 40mg / kg and Gelofen 400mg / kg, and Tt extract 80mg / kg and Gelofen 400mg / kg. Gelofen was prescribed intraperitoneal and Tt was prescribed orally for 21 days. At the end of phlebotomizing the animals, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Anaplastic lymphoma kinase (ALK) levels were measured, and the results were analyzed by ANOVA and Duncan tests. The significant difference in the data was considered P<0.05.
Results: The results showed that the transaminase concentration in the groups receiving Gelofen alone and with the Tt extract in doses of 20mg /kg and 40 mg /kg had a significant increase compared to the control group and the groups receiving Tt alone and Tt with the dose of 80mg/kg with Gelofen, had a significant decrease compared to the control and Gelofen alone groups (P<0.05).
Conclusion: The results showed that the Tt extract led to prevent the negative effects of Gelofen on hepatic tissue in a dose-dependent manner and in result on the serum levels of liver transaminases.

 
Keyword(s): GELOFEN, TRIBULUS TERRESTRIS, ALT, AST, ALK, RAT
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

HEJAZI, L., & HOSSEINI, S. (2016). THE EFFECT OF TRIBULUS TERRESTRIS EXTRACT ON HEPATIC COMPLICATIONS DUE TO THE GELOFEN CONSUMPTION IN ADULT FEMALE RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, 6(2), 155-161. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511650



Vancouver: Copy

HEJAZI L., HOSSEINI S.E.. THE EFFECT OF TRIBULUS TERRESTRIS EXTRACT ON HEPATIC COMPLICATIONS DUE TO THE GELOFEN CONSUMPTION IN ADULT FEMALE RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021July30];6(2):155-161. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511650



IEEE: Copy

HEJAZI, L., HOSSEINI, S., 2016. THE EFFECT OF TRIBULUS TERRESTRIS EXTRACT ON HEPATIC COMPLICATIONS DUE TO THE GELOFEN CONSUMPTION IN ADULT FEMALE RATS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, [online] 6(2), pp.155-161. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511650.



 
 
Persian Abstract Yearly Visit 43
 
 
Latest on Blog
Enter SID Blog