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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   WINTER 2015 , Volume 3 , Number 1; Page(s) 42 To 48.
 
Paper: 

THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE

 
DOI: 

10.18869/acadpub.shefa.3.1.42

 
Author(s):  ZAMANI ESMATI MAHYA, MALEKZADEH HANIEH, JENAB ESFAHANI HANIEH, ESHAGHABADI AREZOU, GHASEMI SEDIGHEH, JAFARIANI MARYAM*
 
* SHEFA NEUROSCIENCE RESEARCH CENTER, KHATAM ALANBIA HOSPITAL, TEHRAN, IRAN
 
Abstract: 

Introduction: Epilepsy is the most common disorder of the central nerves system. Studies showed that carbamazepine has anti-epileptic effects. However, there is no evidence whether carbamazepine protect seizure-induced neuronal injury. In this study, the effects of carbamazepine were evaluated on cell injury observed in pentylenetetrazole (PTZ) model of seizure in the rat brain.
Materials and Methods: The convulsive behaviour and histological evaluation were performed in age- and weight-matched rats, which were divided into five groups: 1.control group: without any intervention, 2. PTZ group: after PTZ injection (40 mg/ kg), 3. Sham group: vehicles were injected 30 min before PTZ injection (40 mg/ kg), 4. Treatment group 1: carbamazepine (10 mg/kg) was injected 30 min before PTZ injection, 5. Treatment group 2: carbamazepine (40 mg/kg) was injected 30 min before PTZ injection.
Results: Carbamazepine significantly decreased production of the dark neurons in the hippocampal CA1 and CA3 areas and the temporal cortex after PTZ-induced seizure compared to PTZ and sham groups. Density of dark neurons in treatment groups was significantly higher than control group.
Conclusion: The results showed that carbamazepine acts as a neuroprotective substance after seizure attacks.

 
Keyword(s): CARBAMAZEPINE, EPILEPSY, SEIZURES, PENTYLENETETRAZOLE, HIPPOCAMPUS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

ZAMANI ESMATI, M., & MALEKZADEH, H., & JENAB ESFAHANI, H., & ESHAGHABADI, A., & GHASEMI, S., & JAFARIANI, M. (2015). THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(1), 42-48. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511648



Vancouver: Copy

ZAMANI ESMATI MAHYA, MALEKZADEH HANIEH, JENAB ESFAHANI HANIEH, ESHAGHABADI AREZOU, GHASEMI SEDIGHEH, JAFARIANI MARYAM. THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM. 2015 [cited 2021September26];3(1):42-48. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511648



IEEE: Copy

ZAMANI ESMATI, M., MALEKZADEH, H., JENAB ESFAHANI, H., ESHAGHABADI, A., GHASEMI, S., JAFARIANI, M., 2015. THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, [online] 3(1), pp.42-48. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511648.



 
 
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