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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   WINTER 2015 , Volume 3 , Number 1; Page(s) 42 To 48.
 
Paper: 

THE EFFECT OF CARBAMAZEPINE ON NEURONAL DAMAGE IN PENTYLENTETRAZOLE MODEL OF SEIZURE

 
DOI: 

10.18869/acadpub.shefa.3.1.42

 
Author(s):  ZAMANI ESMATI MAHYA, MALEKZADEH HANIEH, JENAB ESFAHANI HANIEH, ESHAGHABADI AREZOU, GHASEMI SEDIGHEH, JAFARIANI MARYAM*
 
* SHEFA NEUROSCIENCE RESEARCH CENTER, KHATAM ALANBIA HOSPITAL, TEHRAN, IRAN
 
Abstract: 

Introduction: Epilepsy is the most common disorder of the central nerves system. Studies showed that carbamazepine has anti-epileptic effects. However, there is no evidence whether carbamazepine protect seizure-induced neuronal injury. In this study, the effects of carbamazepine were evaluated on cell injury observed in pentylenetetrazole (PTZ) model of seizure in the rat brain.
Materials and Methods: The convulsive behaviour and histological evaluation were performed in age- and weight-matched rats, which were divided into five groups: 1.control group: without any intervention, 2. PTZ group: after PTZ injection (40 mg/ kg), 3. Sham group: vehicles were injected 30 min before PTZ injection (40 mg/ kg), 4. Treatment group 1: carbamazepine (10 mg/kg) was injected 30 min before PTZ injection, 5. Treatment group 2: carbamazepine (40 mg/kg) was injected 30 min before PTZ injection.
Results: Carbamazepine significantly decreased production of the dark neurons in the hippocampal CA1 and CA3 areas and the temporal cortex after PTZ-induced seizure compared to PTZ and sham groups. Density of dark neurons in treatment groups was significantly higher than control group.
Conclusion: The results showed that carbamazepine acts as a neuroprotective substance after seizure attacks.

 
Keyword(s): CARBAMAZEPINE, EPILEPSY, SEIZURES, PENTYLENETETRAZOLE, HIPPOCAMPUS
 
References: 
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