Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   JULY 2016 , Volume 10 , Number 3; Page(s) 130 To 137.
 
Paper: 

ASSOCIATION BETWEEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) GENE POLYMORPHISMS AND SUSCEPTIBILITY TO CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA IN AN IRANIAN POPULATION

 
 
Author(s):  BAHARI GHOLAMREZA, HASHEMI MOHAMMAD*, NADERI MAJID, TAHERI MOHSEN
 
* DEPARTMENT OF CLINICAL BIOCHEMISTRY, SCHOOL OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IRAN
 
Abstract: 

Background: The present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms and childhood acute lymphoblastic leukemia (ALL) in a sample of Iranian population. Subjects and Methods: A total of 220 subjects including 100 children diagnosed with ALL and 120 healthy children participated in the case-control study. The single nucleotide polymorphisms (SNPs) of MTHFR were determined by ARMS-PCR or PCR-RFLP method. Results: Our investigation revealed that rs13306561 both TC and TC + CC genotypes decreased the risk of ALL compared to TT genotype (OR=0.32, 95%CI=0.15-0.68, p=0.002 and OR=0.35, 95%CI=0.17-0.70, p=0.003, respectively). In addition, the rs13306561 C allele decreased the risk of ALL in comparison with T allele (OR=0.42, 95% CI=0.22-0.78, P=0.005). MTHFR rs1801131 (A1298C) polymorphism showed that the AC heterozygous genotype decreased the risk of ALL in comparison with AA homozygous genotype (OR=0.43, 95%CI=0.21-0.90, p=0.037). Neither the overall Chi-square comparison of cases and control subjects (c2=5.54, p=0.063) nor the logistic regression analysis showed significant association between C677T polymorphism and ALL (OR=1.25, 95% CI=0.69-2.23, p=0.552; CT vs. CC). Conclusion: The current investigation findings showed that MTHFR rs1801131 and rs13306561 polymorphisms decreased the risk of ALL in the population which has been studied. Further studies with larger sample sizes and different ethnicities are required to validate our findings.

 
Keyword(s): MTHFR, POLYMORPHISM, ACUTE LYMPHOCYTIC LEUKEMIA
 
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