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Paper Information

Journal:   NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM   FALL 2014 , Volume 2 , Number 4; Page(s) 60 To 70.
 
Paper: 

IMMUNOMODULATORY ROLE OF MESENCHYMAL STEM CELLS AGAINST MULTIPLE SCLEROSIS

 
DOI: 

10.18869/acadpub.shefa.2.4.60

 
Author(s):  GHAEMI AMIR, BABAEI ABRAKI SHAHNAZ, GHASEMI SEDIGHEH, SAJADIAN AZADEH, TOGHA MANSOUREH*
 
* IRANIAN CENTER OF NEUROLOGICAL RESEARCH, NEUROSCIENCE RESEARCH INSTITUTE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: Multiple sclerosis (MS) is an autoimmune disease of central nervous system that is characterized by the progressive loss of myelin. In addition to immunoregulatory properties, novel MS therapies promote myelin repair activities. Mesenchymal stem cells (MSCs) have been viewed as a potent tool for regenerative and immunosuppressive functions, indicating a potential therapy for MS. MSCs have immunological functions which are exerted by direct cell-to-cell contacts, secretion of stimulatory and inhibitory cytokines, and/or a combination of both mechanisms. Therefore, these cells can inhibit differentiation and proliferation of T-cell and stimulate the Th2 and regulatory T-cells through inhibitory effects on the immune system.
Conclusion: In the current review, we discuss the mechanisms underlying the immunomodulatory effect of MSCs in different experimental models of MS.

 
Keyword(s): CELL- AND TISSUE-BASED THERAPY, IMMUNOMODULATION, MULTIPLE SCLEROSIS, MESENCHYMAL STROMAL CELLS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

GHAEMI, A., & BABAEI ABRAKI, S., & GHASEMI, S., & SAJADIAN, A., & TOGHA, M. (2014). IMMUNOMODULATORY ROLE OF MESENCHYMAL STEM CELLS AGAINST MULTIPLE SCLEROSIS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(4), 60-70. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511583



Vancouver: Copy

GHAEMI AMIR, BABAEI ABRAKI SHAHNAZ, GHASEMI SEDIGHEH, SAJADIAN AZADEH, TOGHA MANSOUREH. IMMUNOMODULATORY ROLE OF MESENCHYMAL STEM CELLS AGAINST MULTIPLE SCLEROSIS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM. 2014 [cited 2021August03];2(4):60-70. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511583



IEEE: Copy

GHAEMI, A., BABAEI ABRAKI, S., GHASEMI, S., SAJADIAN, A., TOGHA, M., 2014. IMMUNOMODULATORY ROLE OF MESENCHYMAL STEM CELLS AGAINST MULTIPLE SCLEROSIS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, [online] 2(4), pp.60-70. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511583.



 
 
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